ANTRECTOMY DOES NOT ACCELERATE REVERSAL OF OMEPRAZOLE-INDUCED TROPHIC EFFECTS IN THE RAT STOMACH

被引:5
作者
AXELSON, J
HAKANSON, R
SUNDLER, F
机构
[1] UNIV LUND,DEPT SURG,S-22101 LUND,SWEDEN
[2] UNIV LUND,DEPT PHARMACOL,S-22101 LUND,SWEDEN
[3] UNIV LUND,DEPT MED CELL RES,S-22101 LUND,SWEDEN
关键词
ANTRECTOMY; ENTEROCHROMAFFIN-LIKE CELLS; GASTRIN; HISTAMINE AND THE OXYNTIC MUCOSA;
D O I
10.3109/00365529208999957
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The oxyntic mucosa in the rat stomach is under the influence of circulating gastrin. The histamine-producing enterochromaffin-like (ECL) cells constitute the major endocrine cell population in the oxyntic mucosa. They are notably sensitive to changes in the serum gastrin concentration and respond to long-term hypergastrinemia with hyperplasia, whereas hypogastrinemia induces hypoplasia. In the present study long-term, sustained hypergastrinemia was induced by daily treatment with a high dose of the proton pump inhibitor omeprazole. After 10 weeks omeprazole-treated and control rats were antrectomized, resulting in prompt hypogastrinemia. Antrectomy was followed by a rapid reduction of the thickness of the oxyntic mucosa and a somewhat slower reduction of the ECL cell number in both omeprazole-treated and control rats. The percentage decrease in the ECL cell number with time was similar in both groups; after 2-3 weeks the ECL cell number was half of that before antrectomy in both groups. Interestingly, however, 12 weeks after antrectomy the ECL cell number in the omeprazole-pretreated rats remained elevated compared with untreated rats. The histamine concentration of the oxyntic mucosa was markedly lowered within a week after antrectomy in both omeprazole-treated and control rats. Although antrectomy induces hypogastrinemia and although atrophy develops rapidly in the oxyntic mucosa, the omeprazole-induced ECL cell hyperplasia was not completely reversed by antrectomy during the 12 weeks of examination.
引用
收藏
页码:243 / 248
页数:6
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