DIVERGENT ILEAL IGF-I AND IGFBP-3 GENE-EXPRESSION AFTER SMALL-BOWEL RESECTION - A NOVEL MECHANISM TO AMPLIFY IGF ACTION

被引：34

作者：

ALBISTON, AL

TAYLOR, RG

HERINGTON, AC

BEVERIDGE, DJ

FULLER, PJ

机构：

[1] PRINCE HENRYS INST MED RES,POB 152,CLAYTON,VIC 3168,AUSTRALIA

[2] ROYAL CHILDRENS HOSP,DEPT SURG,PARKVILLE,VIC 3052,AUSTRALIA

[3] ROYAL CHILDRENS HOSP,DEPT BIOCHEM,PARKVILLE,VIC 3052,AUSTRALIA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1992年 / 83卷 / 2-3期

关键词：

INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3; INSULIN-LIKE GROWTH FACTOR; MASSIVE SMALL BOWEL RESECTION; INTESTINAL ADAPTATION;

D O I：

10.1016/0303-7207(92)90166-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Changes in the levels of ileal insulin-like growth factor-I (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) mRNA in the rat following massive small bowel resection (MSBR) have been investigated with a sensitive S1 nuclease assay. IGF-I mRNA levels vary little over 7 days; in contrast IGFBP-3 mRNA levels decreased to one-third 7 h post-MSBR, and remained suppressed for the length of this study. We postulate that decreased ileal synthesis of IGFBP-3 enhances the ability of IGF-I to stimulate the adaptive response.

引用

页码：R17 / R20

页数：4

共 19 条

[1] CLONING AND CHARACTERIZATION OF THE GROWTH HORMONE-DEPENDENT INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN (IGFBP-3) IN THE RAT [J].