EFFECT OF ANTIOXIDANTS ON ADRIAMYCIN-INDUCED MICROSOMAL LIPID-PEROXIDATION

被引：19

作者：

HIDA, H

COUDRAY, C

CALOP, J

FAVIER, A

机构：

[1] CHR UNIV GRENOBLE,BIOCHIM MICRONUTRIMENTS & RADICAUX LIBRES,F-38043 GRENOBLE,FRANCE

[2] UJF,FAC PHARM,GREPO,LA TRONCHE,FRANCE

[3] UJF,FAC PHARM,PHARM CLIN & BIOTECH LAB,LA TRONCHE,FRANCE

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 1995年 / 47卷 / 1-3期

关键词：

ADRIAMYCIN; LIPID PEROXIDATION; MICROSOMES; ANTIOXIDANTS;

D O I：

10.1007/BF02790107

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adriamycin (25 mu M) stimulated NADPH-dependent microsomal lipid peroxidation about fourfold over control values. The tested antioxidants, zinc, superoxide dismutase, vitamin E, and desferrioxamine (Desferal) inhibited Adriamycin-enhanced lipid peroxidation to varying degrees. Others antioxidants, e.g., glutathione, catalase, and selenium, were found to have no effects. Our in vitro studies suggest that adriamycin effect is mediated by a complex oxyradical cascade involving superoxide, hydroxyl radical, and small amounts of iron.

引用

页码：111 / 116

页数：6

共 13 条

[1] ENHANCEMENT OF DOXORUBICIN TOXICITY FOLLOWING ACTIVATION BY NADPH CYTOCHROME P450 REDUCTASE [J].