NORMAL PROSTAGLANDINURIA E(2) IN GITELMANS SYNDROME, THE HYPOCALCIURIC VARIANT OF BARTTERS-SYNDROME

被引:29
作者
LUTHY, C
BETTINELLI, A
ISELIN, S
METTA, MG
BASILICO, E
OETLIKER, OH
BIANCHETTI, MG
机构
[1] INSELSPITAL BERN,KINDERKLIN,DEPT PEDIAT,DIV PEDIAT NEPHROL,CH-3010 BERN,SWITZERLAND
[2] CLIN PEDIAT SECONDA,DEPT PEDIAT,MILAN,ITALY
关键词
BARTTERS SYNDROME; GITELMANS SYNDROME; PROSTAGLANDIN E(2);
D O I
10.1016/0272-6386(95)90563-4
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
In familial Bartter's syndrome, hyperprostaglandinuria is considered a constant feature and prostanoid synthetase inhibition often positively influences the disease course, The urinary calcium excretion distinguishes two clinically and biochemically different variants, namely, classic Bartter's syndrome (normocalciuric or hypercalciuric variant; urinary calcium to creatinine greater than or equal to 35.3 mg/mg 10(-3)) and Gitelman's syndrome (hypocalciuric variant; urinary calcium to creatinine <35.3 mg/mg 10(-3)). In the hypocalciuric variant of Bartter's syndrome prostanoid synthetase inhibition is of little benefit. Since the production of prostanoids has not been extensively studied in Gitelman's syndrome, the urinary excretion of prostaglandin E(2) was assessed by radioimmunoassay in 11 untreated patients with Gitelman's syndrome (aged 10 to 21 years; five females and six males) and in 11 healthy controls (aged 11 to 20 years; five females and six males). The urinary excretion of prostaglandin E(2) was similar in both study groups. The study provides the rationale for the poor effect of prostanoid synthetase inhibition in the hypocalciuric variant of Bartter's syndrome. The assessment of urinary excretion of prostaglandin E(2) does not represent a diagnostic sine qua non in the context of familial Bartter's syndrome. (C) 1995 by the National Kidney Foundation, Inc.
引用
收藏
页码:824 / 828
页数:5
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