INFLUENCE OF ALKYL CHAIN RAMIFICATION ON ESTRADIOL-RECEPTOR BINDING-AFFINITY AND INTRINSIC ACTIVITY OF 1,2-DIALKYLATED 1,2-BIS(4-HYDROXYPHENYL OR 3-HYDROXYPHENYL)ETHANE ESTROGENS AND ANTIESTROGENS

被引：11

作者：

HARTMANN, RW

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1986年 / 29卷 / 09期

关键词：

D O I：

10.1021/jm00159a018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1668 / 1674

页数：7

共 19 条

[1] Synthetic oestrogenic compounds related to stilbenem and diphenylethane II [J].

Dodds, EC ;

Golberg, L ;

Grunfeld, EI ;

Lawson, W ;

Saffer, CM ;

Robinson, R .

PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1944, 132 (866) :83-101

[2] SECO-ESTRADIOLS AND SOME NON-STEROIDAL ESTROGENS - STRUCTURAL CORRELATES OF ESTROGENIC ACTION [J].

DURANI, S ;

AGARWAL, AK ;

SAXENA, R ;

SETTY, BS ;

GUPTA, RC ;

KOLE, PL ;

RAY, S ;

ANAND, N .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1979, 11 (01) :67-77

[3]

ENGEL J, 1983, DRUGS FUTURE, V8, P413

[4] STRUCTURE-ACTIVITY-RELATIONSHIPS OF ESTROGENS - EFFECTS OF 14-DEHYDROGENATION AND AXIAL METHYL-GROUPS AT C-7, C-9 AND C-11 [J].

GABBARD, RB ;

SEGALOFF, A .

STEROIDS, 1983, 41 (06) :791-805

[5] SCREENING-PROCEDURE FOR THE DEVELOPMENT OF MAMMARY TUMOR-INHIBITING ANTI-ESTROGENS [J].

HARTMANN, RW .

CANCER TREATMENT REVIEWS, 1984, 11 :155-161

[6] RING-SUBSTITUTED 1,2-DIALKYLATED 1,2-BIS(HYDROXYPHENYL)ETHANES .2. SYNTHESIS AND ESTROGEN-RECEPTOR BINDING-AFFINITY OF 4,4'-DISUBSTITUTED, 5,5'-DISUBSTITUTED, AND 6,6'-DISUBSTITUTED METAHEXESTROLS [J].

HARTMANN, RW ;

HEINDL, A ;

SCHONENBERGER, H .

JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (05) :577-585

[7] RING-SUBSTITUTED 1,2-DIALKYLATED 1,2-BIS(HYDROXYPHENYL)ETHANES .1. SYNTHESIS AND ESTROGEN-RECEPTOR BINDING-AFFINITY OF 2,2'- AND 3,3'-DISUBSTITUTED HEXESTROLS [J].

HARTMANN, RW ;

SCHWARZ, W ;

SCHONENBERGER, H .

JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (08) :1137-1144

[8] POTENTIAL ANTI-ESTROGENS - SYNTHESIS AND EVALUATION OF MAMMARY-TUMOR INHIBITING ACTIVITY OF 1,2-DIALKYL-1,2-BIS(3'-HYDROXYPHENYL)ETHANES [J].

HARTMANN, RW ;

BUCHBORN, H ;

KRANZFELDER, G ;

SCHONENBERGER, H ;

BOGDEN, A .

JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (10) :1192-1197

[9] RING-SUBSTITUTED 1,2-DIALKYLATED 1,2-BIS(HYDROXYPHENYL)ETHANES .3. SYNTHESIS, ESTROGEN-RECEPTOR BINDING-AFFINITY, AND EVALUATION OF ANTIESTROGENIC AND MAMMARY-TUMOR INHIBITING ACTIVITY OF 2,2'-DISUBSTITUTED BUTESTROLS AND 6,6'-DISUBSTITUTED METABUTESTROLS [J].

HARTMANN, RW ;

HEINDL, A ;

SCHWARZ, W ;

SCHONENBERGER, H .

JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (07) :819-824

[10] INFLUENCE OF ALKYL-CHAIN FLUORINATION ON THE ACTION OF MAMMARY-TUMOR INHIBITING 2,3-BIS(HYDROXYPHENYL)BUTANES AND 2,3-BIS(HYDROXYPHENYL)BUT-2-ENES [J].

HARTMANN, RW ;

HEINDL, A ;

SCHNEIDER, MR ;

SCHONENBERGER, H .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (03) :322-328

← 1 2 →