5-NITRO-2'-DEOXYURIDYLATE - MECHANISM-BASED INHIBITOR OF THYMIDYLATE SYNTHETASE

被引：25

作者：

MATSUDA, A

WATAYA, Y

SANTI, DV

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1978年 / 84卷 / 03期

关键词：

D O I：

10.1016/0006-291X(78)90755-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：654 / 659

页数：6

共 12 条

[1]

CRUSBERG TC, 1970, J BIOL CHEM, V245, P5292

[2] THYMIDYLATE SYNTHETASE - TARGET ENZYME IN CANCER CHEMOTHERAPY [J].

DANENBERG, PV .

BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 473 (02) :73-92

[3]

DECLERCQ E, 1978, MOL PHARM, V14, P411

[4]

DUNLAP RB, 1971, BIOCHEMISTRY-US, V10, P88, DOI 10.1021/bi00777a014

[5] EFFECT OF SUBSTRATE ANALOGS ON CIRCULAR DICHROIC SPECTRA OF THYMIDYLATE SYNTHETASE FROM LACTOBACILLUS-CASEI [J].

GALIVAN, JH ;

MALEY, GF ;

MALEY, F .

BIOCHEMISTRY, 1975, 14 (15) :3338-3344

[6] NITRATION OF PYRIMIDINE-BASES AND NUCLEOTIDES BY NITRONIUM TETRAFLUOROBORATE - SYNTHESIS OF 5-NITRO-2'-DEOXYURIDINE [J].

HUANG, GF ;

TORRENCE, PF .

JOURNAL OF ORGANIC CHEMISTRY, 1977, 42 (24) :3821-3824

[7] LINEAR FREE-ENERGY RELATIONSHIP GOVERNING COVALENT ADDITION OF ANIONIC REAGENTS TO 1,3-DIMETHYL-5-NITROURACIL [J].

PITMAN, IH ;

CHO, MJ ;

RORK, GS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1974, 96 (06) :1840-1843

[8]

POGOLOTTI AL, 1977, BIOORG CHEM, V1, P277

[9] MECHANISM OF INTERACTION OF THYMIDYLATE SYNTHETASE WITH 5-FLUORODEOXYURIDYLATE [J].

SANTI, DV ;

MCHENRY, CS ;

SOMMER, H .

BIOCHEMISTRY, 1974, 13 (03) :471-481

[10]

WAHBA AJ, 1961, J BIOL CHEM, V236, pPC11

← 1 2 →