ALPHA1-ANTITRYPSIN DEFICIENCY - A DEFECT IN PROTEIN SYNTHESIS

被引：45

作者：

KUEPPERS, F

FALLAT, RJ

机构：

[1] Cardiovascular Research Institute, University of California San Francisco Medical Center, San Francisco

来源：

CLINICA CHIMICA ACTA | 1969年 / 24卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0009-8981(69)90111-9

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The half-life of human α1-antitrypsin in plasma was determined in normal individuals and homozygotes for a deficiency gene. The half-life in normal individuals was 3 days and 22 hours ± 32 hours (S.D.). The deficient individuals had similar values. We conclude that in deficient individuals the catabolic rate of serum α1-antitrypsin is the same as in normals and that consequently a defect in synthesis is probably responsible for the low levels of this protein in plasma. © 1969.

引用

页码：401 / &

共 7 条

[1]

ERICKSSON S, 1965, ACTA MED SCAND S175, V177

[2] PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY [J].