CLINICOPATHOLOGICAL STUDY ON END-STAGE REFLUX NEPHROPATHY IN RENAL-TRANSPLANTED CHILDREN

被引:3
作者
KUNIKATA, S
ISHII, T
NISHIOKA, T
UEMURA, T
WAKABAYASHI, A
KANDA, H
MATSUURA, T
KOHRI, K
AKIYAMA, T
KURITA, T
机构
[1] Department of Urology, Kinki University School of Medicine, Osaka
关键词
Glomerulosclerosis focal and segmental; Reflux nephropathy; Renal transplantation;
D O I
10.1159/000281672
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Five children with end-stage reflux nephropathy underwent kidney transplantation at our clinic. Reflux nephropathy was studied clinically and histologically. All children had proteinuria before starting hemodialysis, and hypertension was present in 2 cases. Three children underwent antireflux operations prior to transplantation. The original kidneys exhibiting reflux were removed during renal transplantation. All original kidneys exhibited atrophy and scarring. Focal and segmental glomerulosclerosis was found in 4 cases. PAS deposition in the interstitium, suggestive of Tamm-Horsfall glycoprotein, was found in all cases. No recurrent signs of focal and segmental glomerulosclerosis have been found in the children who have been followed up from 1 to 6 years after transplantation. © 1990 S. Karger AG, Basel.
引用
收藏
页码:70 / 74
页数:5
相关论文
共 25 条
[1]  
Bailey R.R., Lynn K.L., End-stage reflux nephropathy, Contr Nephrol, 39, pp. 102-110, (1984)
[2]  
Kincaid-Smnith P., Becker G., Reflux nephropathy and chronic atrophic pyelonephritis, a review, J Infect Dis, 138, pp. 774-780, (1978)
[3]  
Lyon R.P., Marshall S.K., Tanagho E.A., The ureteral orifice, its configuration and competency, J Urol, 102, pp. 504-509, (1969)
[4]  
Huland H., Buchardt P., Kollermann M., Et al., Vesicoureteral reflux in end stage renal disease, J Urol, 121, pp. 10-12, (1979)
[5]  
Huland H., Busch R., Chronic pyelonephritis as a cause of end stage renal disease, J Urol, 127, pp. 642-643, (1982)
[6]  
Hodson C.J., Edwards D., Chronic pyelonephritis and vesico-ure- teric reflux, Clin Radiol, 11, pp. 219-231, (1960)
[7]  
Bailey R.R., The relationship of vesicoureteric reflux to urinary tract infection and chronic pyelonephritis reflux nephropathy, Clin Nephrol, 1, pp. 132-141, (1973)
[8]  
Salvatierra O., Tanagho E.A., Reflux as a cause of end stage kidney disease. Report of 32 cases, J Urol, 117, pp. 441-443, (1977)
[9]  
Senekjian H.O., Sinebaugh B.J., Mattioli C.A., Et al., Irreversible renal failure following vesicoureteral reflux, JAMA, 241, pp. 160-162, (1979)
[10]  
Kunikata S., Kohri K., Akiyama T., Et al., The follow-up study of renal function in vesicoureteral reflux, Jap J Urol, 74, pp. 330-338, (1983)