RADIATION-DOSE AND LEUKEMIA RISK - GENERAL RELATIVE RISK TECHNIQUES FOR DOSE-RESPONSE MODELS IN A MATCHED CASE-CONTROL STUDY

被引：21

作者：

BLETTNER, M

BOICE, JD

机构：

[1] Radiation Epidemiology Branch, National Cancer Institute, NIH, Bethesda, Maryland

[2] Department of Epidemiology and Biometry, German Cancer Research Center, Heidelberg, D-6900

来源：

STATISTICS IN MEDICINE | 1991年 / 10卷 / 10期

关键词：

D O I：

10.1002/sim.4780101004

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Generalized relative risk functions were used to model radiation dose-response information from a large matched case-control study of leukaemia occurring after treatment for cervical cancer. Models suggested by radiobiological theory were investigated and compared to standard analyses of categorical dose-response to the linear model. Local radiation doses to each of fourteen bone marrow compartments for each patient were incorporated into the models, and the corresponding risks were summed. Conditional maximum likelihood methods were used to estimate risk parameters. Unique features of the analysis include modelling both induction and reduction of risk as a function of radiation dose absorbed by different parts of the body within individuals. Detailed statistical aspects of these analyses are presented and discussed.

引用

页码：1511 / 1526

页数：16

共 29 条

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