SPLENIC IRRADIATION IN MYELOFIBROSIS - EFFECT ON CIRCULATING MYELOID PROGENITOR CELLS

被引：30

作者：

KOEFFLER, HP ^{[1
]}

CLINE, MJ ^{[1
]}

GOLDE, DW ^{[1
]}

机构：

[1] VET ADM HOSP,SEPULVEDA,CA 91343

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1979年 / 43卷 / 01期

关键词：

D O I：

10.1111/j.1365-2141.1979.tb03721.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Summary. We have investigated the mechanism of splenic irradiation‐induced granulocytopenia in two patients with myelofibrosis and marked splenomegaly. Serial assays were performed for circulating granulocyte‐monocyte progenitors capable of colony formation in vitro (CFU‐C). For comparison, similar studies were performed on two patients receiving whole brain irradiation for glioma. Splenic irradiation caused a significant decrease in circulating CFU‐C in the myelofibrosis patients. There was no decrease in circulating CFU‐C in the brain‐irradiated patients. No radiation‐induced humoral inhibitor of granulopoiesis and no increased CFU‐C radiosensitivity could be demonstrated in the myelofibrosis patients. These observations, taken together with previous data on splenic blood flow and pooling, suggest that the major mechanism of irradiation‐induced granulocytopenia in myelofibrosis is destruction of proliferating precursor cells in the splenic tissue and sinusoids. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：69 / 77

页数：9

共 33 条

[1]

BAGBY GC, 1978, SCAND J HAEMATOL, V20, P193

[2] EFFECT OF SPLENIC IRRADIATION ON CIRCULATING COLONY-FORMING CELLS IN CHRONIC GRANULOCYTIC LEUKEMIA [J].