PRESENTATION OF ANTIGEN BY MIXED ISOTYPE CLASS-II MOLECULES IN NORMAL H-2D MICE

被引:48
作者
RUBERTI, G
SELLINS, KS
HILL, CM
GERMAIN, RN
FATHMAN, CG
LIVINGSTONE, A
机构
[1] STANFORD UNIV,MED CTR,SCH MED,DEPT MED,DIV IMMUNOL & RHEUMATOL,ROOM S021,STANFORD,CA 94305
[2] IMMULOG PHARMACEUT CORP,PALO ALTO,CA 94304
[3] NIAID,IMMUNOL LAB,BETHESDA,MD 20892
[4] BASEL INST IMMUNOL,CH-4005 BASEL,SWITZERLAND
关键词
D O I
10.1084/jem.175.1.157
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A panel of DBA/2 T cell hybridomas specific for the sperm whale myoglobin epitope 110-121 was found to recognize antigen presented by the mixed isotype class II molecule E-alpha(d)A-beta(d). The response was blocked by monoclonal antibodies specific for E-alpha and A-beta(d) chains; in addition, the hybridomas responded to antigen presented by L cells expressing E-alpha(A)beta(d) molecules, and made no response with L cells expressing I-A(d) or I-E(d) molecules. Two more groups of hybridomas isolated from DBA/2 and B10.D2 mice immunized with myoglobin also recognized peptide 110-121 presented by E-alpha(d)A-beta(d). Thus, although it is expressed at biochemically undetectable levels on spleen cells, the E-alpha(d)A-beta(d) molecule is an important presenting element in normal H-2d mice making a conventional immune response to a protein antigen. These results suggest that high levels of class II expression are not a prerequisite for T cell activation.
引用
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页码:157 / 162
页数:6
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