THE SECONDARY STRUCTURE OF INFLUENZA-A M2 TRANSMEMBRANE DOMAIN - A CIRCULAR-DICHROISM STUDY

被引:65
作者
DUFF, KC
KELLY, SM
PRICE, NC
BRADSHAW, JP
机构
[1] UNIV EDINBURGH,SCH MED,DEPT BIOCHEM,EDINBURGH EH8 9XD,SCOTLAND
[2] UNIV STIRLING,DEPT BIOL & MOLEC SCI,STIRLING FK9 4LA,SCOTLAND
关键词
SPECTROPHOTOMETRY; CIRCULAR DICHROISM; INFLUENZA M2-PROTEIN; ION CHANNEL;
D O I
10.1016/0014-5793(92)81114-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Using circular dichroism, this study investigated the secondary structure of the influenza A M2 transmembrane domain. When reconstituted into 1,2-dioleoyl-sn-glycero-3-phosphocholine liposomes, the M2 transmembrane domain was found to adopt a predominantly alpha-helical secondary structure which was unaffected by both temperature and the addition of 1-aminoadamantane hydrochloride. Reconstitution into 1,2-dioleoyl-sn-glycero-3-phosphoglycerol liposomes resulted in a marked decrease in helical content.
引用
收藏
页码:256 / 258
页数:3
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