CANCER RISK IN PRIMARY BILIARY-CIRRHOSIS - A POPULATION-BASED STUDY FROM SWEDEN

被引：74

作者：

LOOF, L

ADAMI, HO

SPAREN, P

DANIELSSON, A

ERIKSSON, LS

HULTCRANTZ, R

LINDGREN, S

OLSSON, R

PRYTZ, H

RYDEN, BO

SANDBERGGERTZEN, H

WALLERSTEDT, S

机构：

[1] UNIV UPPSALA HOSP, CANC EPIDEMIOL UNIT, S-75185 UPPSALA, SWEDEN

[2] HARVARD UNIV, SCH PUBL HLTH, DEPT EPIDEMIOL, BOSTON, MA 02115 USA

[3] UMEA UNIV HOSP, DEPT INTERNAL MED, S-90185 UMEA, SWEDEN

[4] HUDDINGE HOSP, STOCKHOLM, SWEDEN

[5] KAROLINSKA HOSP, STOCKHOLM, SWEDEN

[6] MALMO GEN HOSP, S-21401 MALMO, SWEDEN

[7] SAHLGRENS UNIV HOSP, GOTHENBURG, SWEDEN

[8] UNIV LUND HOSP, S-22185 LUND, SWEDEN

[9] MOTALA HOSP, MOTALA, SWEDEN

[10] OREBRO MED CTR HOSP, S-70185 OREBRO, SWEDEN

[11] OSTRA HOSP, S-41685 GOTHENBURG, SWEDEN

来源：

HEPATOLOGY | 1994年 / 20卷 / 01期

关键词：

D O I：

10.1016/0270-9139(94)90140-6

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A cohort of 559 patients in Sweden who satisfied predetermined criteria for the diagnosis of primary biliary cirrhosis was followed with respect to the incidence of cancer during the period of 1958 to 1988. The mean follow-up time from the time of primary biliary cirrhosis diagnosis was 9.0 +/- 5.4 yr. During the follow-up period, 148 patients died and the primary cause of death was liver insufficiency. An overall excess risk for cancer, standardized incidence ratio 1.6; 95% confidence interval, 1.1 to 2.2, was found in the cohort. In contrast to previous reports, we found no excess risk for breast cancer (standardized incidence ratio, 0.9; 95% confidence interval, 0.3 to 2.1). The number of hepatocellular cancers in the primary biliary cirrhosis cohort did not significantly differ from expected (standardized incidence ratio, 2.91; 95% confidence interval, 0.4 to 10.5).

引用

页码：101 / 104

页数：4

共 24 条

[1] ALCOHOLISM AND LIVER-CIRRHOSIS IN THE ETIOLOGY OF PRIMARY LIVER-CANCER [J].