KOUMBALONE-A AND KOUMBALONE-B, NEW CASBANE DITERPENES FROM MAPROUNEA-AFRICANA

被引：14

作者：

KASHMAN, Y ^{[1
]}

BERNART, MW ^{[1
]}

TISCHLER, M ^{[1
]}

CARDELLINA, JH ^{[1
]}

BOYD, MR ^{[1
]}

机构：

[1] NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,DRUG DISCOVERY RES & DEV LAB,FREDERICK,MD 21702

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 03期

关键词：

D O I：

10.1021/np50105a020

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The organic extract of Mapronnea africana yielded koumbalones A [1] and B [2], defined by spectral methods as new variations on the casbane ring system. The gross structures, relative configurations, and solution conformations were determined by a combination of spectral analyses and molecular modeling. Because koumbalone A spontaneously converts to koumbalone B at room temperature, koumbalone B may be an artifact of isolation.

引用

页码：426 / 430

页数：5

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