ENANTIOSPECIFIC CONJUGATE ADDITION OF N-NUCLEOPHILES TO SUBSTITUTED FUMARIC ACIDS USING METHYLASPARTASE

被引：11

作者：

GULZAR, MS ^{[1
]}

AKHTAR, M ^{[1
]}

GANI, D ^{[1
]}

机构：

[1] UNIV ST ANDREWS,SCH CHEM,ST ANDREWS KY16 9ST,FIFE,SCOTLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 13期

关键词：

D O I：

10.1039/c39940001601

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In addition to ammonia, 3-methylaspartase is able to catalyse the conjugate addition of hydrazine, hydroxylamine, methoxylamine and alkylamines to various alkyl- and halogenofumaric acids to give single enantiomers of the corresponding N-substituted aspartic acids.

引用

页码：1601 / 1602

页数：2

共 8 条

[1] ENANTIOSPECIFIC SYNTHESIS OF 3-SUBSTITUTED ASPARTIC ACIDS VIA ENZYMIC AMINATION OF SUBSTITUTED FUMARIC ACIDS [J].

AKHTAR, M ;

BOTTING, NP ;

COHEN, MA ;

GANI, D .

TETRAHEDRON, 1987, 43 (24) :5899-5908

[2] KINETICS AND MECHANISM OF SYN-ELIMINATION OF AMMONIA FROM (2S,3R)-3-METHYLASPARTIC ACID BY METHYLASPARTASE [J].

ARCHER, CH ;

GANI, D .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1993, (02) :140-142

[3]

BOTTING NP, 1992, BIOCHEMISTRY-US, V32, P1509

[4]

FUJII T, 1967, CHEM PHARM BULL, V15, P345

[5] CLONING, SEQUENCING, AND EXPRESSION IN ESCHERICHIA-COLI OF THE CLOSTRIDIUM-TETANOMORPHUM GENE ENCODING BETA-METHYLASPARTASE AND CHARACTERIZATION OF THE RECOMBINANT PROTEIN [J].

GODA, SK ;

MINTON, NP ;

BOTTING, NP ;

GANI, D .

BIOCHEMISTRY, 1992, 31 (44) :10747-10756

[6]

Hanson K. R., 1972, ENZYMES, V7, P75

[7] STUDIES OF N-OXIDES OF N,N-DIALKYLAMINO ACIDS .3. SYNTHESES OF N,N-DIMETHYL ACIDIC AMINO ACIDS AND RELATED COMPOUNDS [J].

IKUTANI, Y .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1970, 43 (11) :3602-+

[8]

LUTZ O, 1930, CHEM BER, V63, P448

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