INDEPENDENT CONTROL OF TRANSCRIPTION INITIATIONS FROM 2 SITES BY AN INITIATOR-LIKE ELEMENT AND TATA BOX IN THE HUMAN C-ERBB-2 PROMOTER

被引：14

作者：

MIZUGUCHI, G

KANEIISHII, C

SAWAZAKI, T

HORIKOSHI, M

ROEDER, RG

YAMAMOTO, T

ISHII, S

机构：

[1] INST PHYS & CHEM RES,TSUKUBA LIFE SCI CTR,GENET MOLEC LAB,TSUKUBA,IBARAKI 305,JAPAN

[2] ROCKEFELLER UNIV,BIOCHEM & MOLEC BIOL LAB,NEW YORK,NY 10021

[3] UNIV TOKYO,INST MOLEC & CELLULAR BIOSCI,BUNKYO KU,TOKYO 113,JAPAN

[4] UNIV TOKYO,INST MED SCI,DEPT ONCOL,MINATO KU,TOKYO 108,JAPAN

[5] SCI UNIV TOKYO,FAC PHARMACEUT SCI,SHINJUKU KU,TOKYO 162,JAPAN

来源：

FEBS LETTERS | 1994年 / 348卷 / 01期

基金：

美国国家卫生研究院;

关键词：

C-ERBB-2; PROTOONCOGENE; TRANSCRIPTIONAL INITIATION; INITIATOR; TATA BOX;

D O I：

10.1016/0014-5793(94)00578-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcription of the human c-erbB-2-proto-oncogene starts mainly at two sites, nucleotide positions +1 and -69. The present studies have identified an initiator-like element that specifies the position of transcription initiation at position -69. This initiator-like element contains six GGA repeats and is located just downstream from the transcription start site between positions -68 and -45. In addition, both in vitro and in vivo studies indicated that transcription initiation at position +1 is specified by a TATA box 25 bp upstream from the transcription startpoint. Thus, initiation at two sites in the c-erbB-2 promoter is controlled independently by the initiator-like element and the TATA box.

引用

页码：80 / 88

页数：9

共 63 条

[1] THE PRODUCT OF THE HUMAN C-ERBB-2 GENE - A 185-KILODALTON GLYCOPROTEIN WITH TYROSINE KINASE-ACTIVITY [J].