INHIBITION OF MUCOCILIARY CLEARANCE OF THE EUSTACHIAN-TUBE BY LEUKOTRIENES C4 AND D4

被引：22

作者：

GANBO, T ^{[1
]}

HISAMATSU, K ^{[1
]}

SHIMOMURA, S ^{[1
]}

NAKAJIMA, T ^{[1
]}

INOUE, H ^{[1
]}

MURAKAMI, Y ^{[1
]}

机构：

[1] ST MARIANNA UNIV, SCH MED, DEPT PLAST & RECONSTRUCT SURG, KAWASAKI, KANAGAWA, JAPAN

来源：

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY | 1995年 / 104卷 / 03期

关键词：

CHINCHILLA; CILIARY MOVEMENT; MUCOCILIARY TRANSPORT; OTITIS MEDIA WITH EFFUSION;

D O I：

10.1177/000348949510400309

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The effect of leukotrienes C4 (LTC4) and D4 (LTD4) and prostaglandin E2 (PGE2) on mucociliary clearance of the eustachian cube was investigated in vitro and in vivo. Normal ciliated epithelium was obtained from the eustachian tube of guinea pigs and incubated separately with LTC4 LTD4, and PGE2 at concentrations of 10(-8) mol/L and 10(-6) mol/L. Ciliary activity was measured photoelectrically. Leukotriene D4 progressively inhibited ciliary activity, while PGE2 promoted it. Leukotriene C4 also induced ciliary inhibition. One milliliter each of 10(-5) mol/L LTC4 LTD4 and PGE2 was directly injected into the tympanic bullae of chinchillas under anesthesia. The middle ears were examined by otomicroscopy, tympanometry, and auditory brain stem response over time. Clearance of middle ear effusion was delayed by LTC4 and LTD4, as compared with PGE2 and the control. These findings indicate that LTC4 and LTD4 inhibit mucociliary clearance of the eustachian tube.

引用

页码：231 / 236

页数：6

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