ALLOSTERIC INTERACTION OF METAL-IONS WITH SACCHARIDES IN A CROWNED DIBORONIC ACID

被引：89

作者：

DENG, G ^{[1
]}

JAMES, TD ^{[1
]}

SHINKAI, S ^{[1
]}

机构：

[1] RES DEV CORP JAPAN,CHEMIRECOGN PROJECT,KURUME,FUKUOKA 830,JAPAN

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1994年 / 116卷 / 11期

关键词：

D O I：

10.1021/ja00090a004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A diboronic acid saccharide (covalent) receptor site and a crown metal ion (electrostatic) receptor site are successfully coupled in an allosteric system. The binding of monosaccharides with 2b as intramolecular 1:1 complexes was monitored by circular dichroism (CD). Added calcium perchlorate reduces the binding of the 1:1 saccharide complexes as followed by a decrease in the CD activity. This is a novel allosteric system which mimics the action of the Na+/D-glucose cotransport protein in nature.

引用

页码：4567 / 4572

页数：6

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