A GENETIC-LINKAGE MAP OF THE LABORATORY RAT, RATTUS-NORVEGICUS

被引：444

作者：

JACOB, HJ

BROWN, DM

BUNKER, RK

DALY, MJ

DZAU, VJ

GOODMAN, A

KOIKE, G

KREN, V

KURTZ, T

LERNMARK, A

LEVAN, G

MAO, YP

PETTERSSON, A

PRAVENEC, M

SIMON, JS

SZPIRER, C

SZPIRER, J

TROLLIET, MR

WINER, ES

LANDER, ES

机构：

[1] MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

[2] STANFORD UNIV, CARDIOVASC RES CTR, PALO ALTO, CA USA

[3] UNIV CALIF SAN FRANCISCO, DEPT LAB MED, SAN FRANCISCO, CA 94143 USA

[4] GOTHENBURG UNIV, GOTHENBURG, SWEDEN

[5] KAROLINSKA INST, DEPT MOLEC MED, STOCKHOLM, SWEDEN

[6] FREE UNIV BRUSSELS, BRUSSELS, BELGIUM

[7] CHARLES UNIV, DEPT BIOL, PRAGUE, CZECH REPUBLIC

[8] ACAD SCI CZECH REPUBL, INST PHYSIOL, PRAGUE, CZECH REPUBLIC

[9] MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA

来源：

NATURE GENETICS | 1995年 / 9卷 / 01期

关键词：

D O I：

10.1038/ng0195-63

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report the construction of the first complete genetic linkage map of the laboratory rat. By testing 1171 simple sequence length polymorphisms (SSLPs), we have identified 432 markers that show polymorphisms between the SHR and BN rat strains and mapped them in a single (SHR x BN) F-2 intercross. The loci define 21 large linkage groups corresponding to the 21 rat chromosomes, together with a pair of nearby markers on chromosome 9 that are not linked to the rest of the map. Because 99.5% of the markers fall into one of the 21 large linkage groups, the maps appear to cover the vast majority of the rat genome. The availability of the map should facilitate whole genome scans for genes underlying qualitative and quantitative traits relevant to mammalian physiology and pathobiology.

引用

页码：63 / 69

页数：7

共 49 条

[1] THE SYNAPTOPHYSIN-ENCODING GENE IN RAT AND MAN IS SPECIFICALLY TRANSCRIBED IN NEUROENDOCRINE CELLS [J].