STRUCTURAL REQUIREMENTS FOR BIOACTIVATION OF ANTICONVULSANTS TO CYTO-TOXIC METABOLITES INVITRO

被引:28
作者
RILEY, RJ [1 ]
KITTERINGHAM, NR [1 ]
PARK, BK [1 ]
机构
[1] UNIV LIVERPOOL,DEPT PHARMACOL & THERAPEUT,POB 147,LIVERPOOL L69 3BX,ENGLAND
关键词
D O I
10.1111/j.1365-2125.1989.tb03530.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:482 / 487
页数:6
相关论文
共 23 条
[1]  
BOYUM A, 1984, METHOD ENZYMOL, V108, P88
[2]  
CHOW SA, 1982, DRUG METAB DISPOS, V10, P156
[3]   IMINOSTILBENE - METABOLITE OF CARBAMAZEPINE ISOLATED FROM RAT URINE [J].
CSETENYI, J ;
BAKER, KM ;
FRIGERIO, A ;
MORSELLI, PL .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1973, 25 (04) :340-341
[4]  
GERSON WT, 1983, BLOOD, V61, P889
[5]  
GROSSMAN SJ, 1988, J PHARMACOL EXP THER, V244, P118
[6]   ENZYMATIC ACTIVATION OF CHEMICALS TO TOXIC METABOLITES [J].
GUENGERICH, FP ;
LIEBLER, DC .
CRC CRITICAL REVIEWS IN TOXICOLOGY, 1985, 14 (03) :259-307
[7]   SPECIES-DIFFERENCES IN THE CYTO-TOXIC AND GENOTOXIC EFFECTS OF 2-ACETYLAMINOFLUORENE AND ITS PRIMARY METABOLITES 2-AMINOFLUORENE AND N-OH-2-ACETYLAMINOFLUORENE [J].
HOLME, JA ;
SODERLUND, EJ .
CARCINOGENESIS, 1985, 6 (03) :421-425
[8]   PHARMACOLOGICAL INHIBITION OF ALDOSE REDUCTASE IN HUMAN DIABETIC NEUROPATHY [J].
JASPAN, J .
DRUGS, 1986, 32 :23-29
[9]   ARENE OXIDES - NEW ASPECT OF DRUG-METABOLISM [J].
JERINA, DM ;
DALY, JW .
SCIENCE, 1974, 185 (4151) :573-582
[10]  
LERTRATANANGKOON K, 1982, DRUG METAB DISPOS, V10, P1