NOVEL PUTATIVE PROTEIN TYROSINE PHOSPHATASES IDENTIFIED BY THE POLYMERASE CHAIN-REACTION

被引：24

作者：

NISHI, M

OHAGI, S

STEINER, DF

机构：

[1] UNIV CHICAGO,HOWARD HUGHES MED INST,5841 S MARYLAND AVE,BOX 23,CHICAGO,IL 60637

[2] UNIV CHICAGO,DEPT BIOCHEM & MOLEC BIOL,CHICAGO,IL 60637

来源：

FEBS LETTERS | 1990年 / 271卷 / 1-2期

关键词：

Gene family; Growth regulatory gene; Polymerase chain reaction; Protein tyrosine phosphatase (human liver); Tyrosine phosphorylation;

D O I：

10.1016/0014-5793(90)80400-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein tyrosine phosphatases (PTPases) are a family of enzymes that specifically dephosphorylate phosphotyrosyl residues in selected protein substrates. To more fully understand the regulatory role of protein tyrosine phosphorylation and dephosphorylation in cellular signal transduction, characterization of PTPases is essential. Using the polymerase chain reaction and degenerate oligonucleotide primers corresponding to conserved amino acid sequences within the catalytic domain of PTPases, we have identified 11 PTPase-related human liver cDNA sequences. Five of these have not been described previously. These results indicate that, like protein tyrosine kinases. PTPases may also comprise a gene family with a large number of members. © 1990.

引用

页码：178 / 180

页数：3

共 18 条

[1] EXPRESSION OF VOLTAGE-GATED K+ CHANNELS IN INSULIN-PRODUCING CELLS - ANALYSIS BY POLYMERASE CHAIN-REACTION
BETSHOLTZ, C
BAUMANN, A
KENNA, S
ASHCROFT, FM
ASHCROFT, SJH
BERGGREN, PO
GRUPE, A
PONGS, O
RORSMAN, P
SANDBLOM, J
WELSH, M
[J]. FEBS LETTERS, 1990, 263 (01) : 121 - 126
[2] HUMAN-PLACENTA PROTEIN-TYROSINE-PHOSPHATASE - AMINO-ACID SEQUENCE AND RELATIONSHIP TO A FAMILY OF RECEPTOR-LIKE PROTEINS
CHARBONNEAU, H
TONKS, NK
KUMAR, S
DILTZ, CD
HARRYLOCK, M
COOL, DE
KREBS, EG
FISCHER, EH
WALSH, KA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (14) : 5252 - 5256
[3] CLONING OF A CDNA FOR A MAJOR HUMAN PROTEIN-TYROSINE-PHOSPHATASE
CHERNOFF, J
SCHIEVELLA, AR
JOST, CA
ERIKSON, RL
NEEL, BG
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (07) : 2735 - 2739
[4] MICROINJECTION OF A PROTEIN-TYROSINE-PHOSPHATASE INHIBITS INSULIN ACTION IN XENOPUS OOCYTES
CICIRELLI, MF
TONKS, NK
DILTZ, CD
WEIEL, JE
FISCHER, EH
KREBS, EG
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) : 5514 - 5518
[5] CDNA ISOLATED FROM A HUMAN T-CELL LIBRARY ENCODES A MEMBER OF THE PROTEIN-TYROSINE-PHOSPHATASE FAMILY
COOL, DE
TONKS, NK
CHARBONNEAU, H
WALSH, KA
FISCHER, EH
KREBS, EG
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (14) : 5257 - 5261
[6] CLONING AND EXPRESSION OF A PROTEIN-TYROSINE-PHOSPHATASE
GUAN, KL
HAUN, RS
WATSON, SJ
GEAHLEN, RL
DIXON, JE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) : 1501 - 1505
[7] PROTEIN-TYROSINE KINASES
HUNTER, T
COOPER, JA
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1985, 54 : 897 - 930
[8] IDENTIFICATION OF AN ADDITIONAL MEMBER OF THE PROTEIN-TYROSINE-PHOSPHATASE FAMILY - EVIDENCE FOR ALTERNATIVE SPLICING IN THE TYROSINE PHOSPHATASE DOMAIN
MATTHEWS, RJ
CAHIR, ED
THOMAS, ML
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (12) : 4444 - 4448
[9] RAPID ACTIVATION OF THE T-CELL TYROSINE PROTEIN-KINASE PP56LCK BY THE CD45 PHOSPHOTYROSINE PHOSPHATASE
MUSTELIN, T
COGGESHALL, KM
ALTMAN, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (16) : 6302 - 6306
[10] EXPRESSION OF CD45 ALTERS PHOSPHORYLATION OF THE LCK-ENCODED TYROSINE PROTEIN-KINASE IN MURINE LYMPHOMA T-CELL LINES
OSTERGAARD, HL
SHACKELFORD, DA
HURLEY, TR
JOHNSON, P
HYMAN, R
SEFTON, BM
TROWBRIDGE, IS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) : 8959 - 8963

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