BEHAVIORAL ACTIVATION INDUCED IN THE RAT BY SUBSTANCE-P INFUSION INTO VENTRAL TEGMENTAL AREA - IMPLICATION OF DOPAMINERGIC A10 NEURONS

被引：97

作者：

KELLEY, AE ^{[1
]}

STINUS, L ^{[1
]}

IVERSEN, SD ^{[1
]}

机构：

[1] UNIV BORDEAUX 2, PSYCHOPHYSIOL LAB, F-33067 BORDEAUX, FRANCE

来源：

NEUROSCIENCE LETTERS | 1979年 / 11卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0304-3940(79)90018-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The functional role of the putative transmitter substance P (SP) was studied using a behavioural approach. SP infusion into the ventral tegmental area in awake rats elicited an increase in locomotor activity which could be blocked by either infusion of a neuroleptic into the nucleus accumbens septi (NAS) or by 6-hydroxydopamine (6-OHDA) lesions of the ascending dopaminergic A10 neurones. Our results suggest that SP induces its behavioral effects through activation of dopaminergic A10 neurones, and imply that endogenous SP may have an important modulatory role. © 1979.

引用

页码：335 / 339

页数：5

共 19 条

[1] REGIONAL DISTRIBUTION OF SUBSTANCE-P IN BRAIN OF RAT [J].

BROWNSTEIN, MJ ;

MROZ, EA ;

KIZER, JS ;

PALKOVITS, M ;

LEEMAN, SE .

BRAIN RESEARCH, 1976, 116 (02) :299-305

[2] EFFECTS OF INTRANIGRAL APPLICATION OF DOPAMINE AND SUBSTANCE-P ON INVIVO RELEASE OF NEWLY SYNTHESIZED [DOPAMINE-H-3 IN IPSILATERAL CAUDATE-NUCLEUS OF CAT [J].

CHERAMY, A ;

NIEOULLON, A ;

MICHELOT, R ;

GLOWINSKI, J .

NEUROSCIENCE LETTERS, 1977, 4 (02) :105-109

[3] AUTORADIOGRAPHIC TRACING OF NUCLEUS ACCUMBENS EFFERENTS IN RAT [J].

CONRAD, LCA ;

PFAFF, DW .

BRAIN RESEARCH, 1976, 113 (03) :589-596

[4] PHARMACOLOGICAL AND ANATOMICAL SUBSTRATES OF AMPHETAMINE RESPONSE IN RAT [J].

CREESE, I ;

IVERSEN, SD .

BRAIN RESEARCH, 1975, 83 (03) :419-436

[5]

CUELLO AC, 1978, BRAIN RES, V149, P413

[6]

CUELLO AC, 1973, J NEUROCHEM, V21, P1337

[7]

CUELLO AC, 1977, CENTRALLY ACTING PEP

[8] CATECHOLAMINE INNERVATION OF BASAL FOREBRAIN .4. TOPOGRAPHY OF DOPAMINE PROJECTION TO BASAL FOREBRAIN AND NEOSTRIATUM [J].

FALLON, JH ;

MOORE, RY .

JOURNAL OF COMPARATIVE NEUROLOGY, 1978, 180 (03) :545-+

[9] AFFERENT CONNECTIONS OF HABENULAR NUCLEI IN RAT - HORSERADISH-PEROXIDASE STUDY, WITH A NOTE ON FIBER-OF-PASSAGE PROBLEM [J].

HERKENHAM, M ;

NAUTA, WJH .

JOURNAL OF COMPARATIVE NEUROLOGY, 1977, 173 (01) :123-145

[10] SUBSTANCE-P - LOCALIZATION IN CENTRAL NERVOUS-SYSTEM AND IN SOME PRIMARY SENSORY NEURONS [J].

HOKFELT, T ;

KELLERTH, JO ;

NILSSON, G ;

PERNOW, B .

SCIENCE, 1975, 190 (4217) :889-890

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