A CLONAL ANALYSIS OF GLIAL LINEAGES IN NEONATAL FOREBRAIN DEVELOPMENT INVITRO

被引:79
作者
VAYSSE, PJJ
GOLDMAN, JE
机构
[1] Department of Pathology Columbia University College of Physicians and Surgeons New York
关键词
D O I
10.1016/0896-6273(90)90160-H
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Retrovirus-mediated gene transfer combined with triple immunostaining for astro- and oligodendroglial markers antibodies to glial fibrillary acidic protein, GD3 ganglioside, and galactocerebroside, and the 04 antibody) was used to study clonal aspects of glial lineage in primary cultures of the neonatal rat striatum. We found two major clonal populations: astrocyte clones containing GFAP+, but GD3-, O4-, and GC- cells, and oligodendrocyte clones containing cells expressing various combinations of GD3, 04, and GC, with rare GFAP+ cells. These results indicate that astrocytes and oligodendrocytes belong to separate lineages in forebrain postnatal development. © 1990.
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页码:227 / 235
页数:9
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