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ANTIBACTERIAL ACTIVITY OF 4 CEPHALOSPORINS IN AN EXPERIMENTAL-INFECTION IN RELATION TO INVITRO EFFECT AND PHARMACOKINETICS
被引:26
作者
:
MATTIE, H
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Infectious Diseases, University Hospital Leiden
MATTIE, H
VANDOKKUM, AM
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Infectious Diseases, University Hospital Leiden
VANDOKKUM, AM
BRUSWEIJER, L
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Infectious Diseases, University Hospital Leiden
BRUSWEIJER, L
KRUL, AM
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Infectious Diseases, University Hospital Leiden
KRUL, AM
VANSTRIJEN, E
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Infectious Diseases, University Hospital Leiden
VANSTRIJEN, E
机构
:
[1]
Department of Infectious Diseases, University Hospital Leiden
来源
:
JOURNAL OF INFECTIOUS DISEASES
|
1990年
/ 162卷
/ 03期
关键词
:
D O I
:
10.1093/infdis/162.3.717
中图分类号
:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号
:
100102 ;
摘要
:
The in vitro activity of four cephalosporins was compared with their effects in an experimental thigh infection (cefuroxime and cefamandole against Escherichia coli and cefamandole, ceftriaxone, and ceftazidime against Klebsiella pneumoniae) in granulocytopenic mice. The effect in vitro (ER) was defined as the difference between the growth rate without antibiotic and the growth rate at the steepest part of a 3-h growth curve in the presence of an antibiotic. The relation between concentration and ER was described with the Hill equation. Using pharmacokinetic parametERs ofthe plasmaconcentrations in vivo and those ofthe Hill equation thecorresponding time course of ER was calculated and by integration with respect to time (∫0tERdt), an estimate was obtained of the effect on bactERia. For all four antibiotics this estimate was significantly correlated with the actual values of the effect in vivo (EN), defined as the difference in numbers of bacteria between controls and antibiotic-treated animals at 4 h. © 1990, by The University of Chicago.
引用
收藏
页码:717 / 722
页数:6
相关论文
共 14 条
[1]
ROLE OF PHARMACOKINETICS IN THE OUTCOME OF INFECTIONS
[J].
DRUSANO, GL
论文数:
0
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0
h-index:
0
DRUSANO, GL
.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,
1988,
32
(03)
:289
-297
[2]
FLANDERS H, 1985, CALCULUS
[3]
CLINICAL PHARMACOLOGY OF CEFAMANDOLE AS COMPARED WITH CEPHALOTHIN
[J].
FONG, IW
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
FONG, IW
;
RALPH, ED
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
RALPH, ED
;
ENGELKING, ER
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
ENGELKING, ER
;
KIRBY, WMM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
KIRBY, WMM
.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,
1976,
9
(01)
:65
-69
[4]
EXPERIMENTAL-INFECTION WITH STREPTOCOCCUS-PNEUMONIAE IN MICE - CORRELATION OF INVITRO ACTIVITY AND PHARMACOKINETIC PARAMETERS WITH INVIVO EFFECT FOR 14 CEPHALOSPORINS
[J].
FRIMODTMOLLER, N
论文数:
0
引用数:
0
h-index:
0
机构:
STATENS SERUM INST,DEPT ANTHROPOL,DK-2300 COPENHAGEN S,DENMARK
FRIMODTMOLLER, N
;
BENTZON, MW
论文数:
0
引用数:
0
h-index:
0
机构:
STATENS SERUM INST,DEPT ANTHROPOL,DK-2300 COPENHAGEN S,DENMARK
BENTZON, MW
;
THOMSEN, VF
论文数:
0
引用数:
0
h-index:
0
机构:
STATENS SERUM INST,DEPT ANTHROPOL,DK-2300 COPENHAGEN S,DENMARK
THOMSEN, VF
.
JOURNAL OF INFECTIOUS DISEASES,
1986,
154
(03)
:511
-517
[5]
ANTIBIOTIC-THERAPY OF INFECTIONS DUE TO PSEUDOMONAS-AERUGINOSA IN NORMAL AND GRANULOCYTOPENIC MICE - COMPARISON OF MURINE AND HUMAN PHARMACOKINETICS
[J].
GERBER, AU
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BERN,INSELSPITAL,DEPT MED,CH-3010 BERN,SWITZERLAND
GERBER, AU
;
BRUGGER, HP
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BERN,INSELSPITAL,DEPT MED,CH-3010 BERN,SWITZERLAND
BRUGGER, HP
;
FELLER, C
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BERN,INSELSPITAL,DEPT MED,CH-3010 BERN,SWITZERLAND
FELLER, C
;
STRITZKO, T
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BERN,INSELSPITAL,DEPT MED,CH-3010 BERN,SWITZERLAND
STRITZKO, T
;
STALDER, B
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BERN,INSELSPITAL,DEPT MED,CH-3010 BERN,SWITZERLAND
STALDER, B
.
JOURNAL OF INFECTIOUS DISEASES,
1986,
153
(01)
:90
-97
[6]
UNDERSTANDING THE DOSE-EFFECT RELATIONSHIP - CLINICAL-APPLICATION OF PHARMACOKINETIC-PHARMACODYNAMIC MODELS
[J].
HOLFORD, NHG
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO, SCH MED, DEPT MED, DIV CLIN PHARMACOL, SAN FRANCISCO, CA 94143 USA
HOLFORD, NHG
;
SHEINER, LB
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO, SCH MED, DEPT MED, DIV CLIN PHARMACOL, SAN FRANCISCO, CA 94143 USA
SHEINER, LB
.
CLINICAL PHARMACOKINETICS,
1981,
6
(06)
:429
-453
[7]
THE EFFICACY OF RIFAMPICIN AGAINST STAPHYLOCOCCUS-AUREUS INVITRO AND IN AN EXPERIMENTAL-INFECTION IN NORMAL AND GRANULOCYTOPENIC MICE
[J].
HOOGETERP, JJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV HOSP LEIDEN,DEPT INFECT DIS,POB 9600,2300 RC LEIDEN,NETHERLANDS
UNIV HOSP LEIDEN,DEPT INFECT DIS,POB 9600,2300 RC LEIDEN,NETHERLANDS
HOOGETERP, JJ
;
MATTIE, H
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV HOSP LEIDEN,DEPT INFECT DIS,POB 9600,2300 RC LEIDEN,NETHERLANDS
UNIV HOSP LEIDEN,DEPT INFECT DIS,POB 9600,2300 RC LEIDEN,NETHERLANDS
MATTIE, H
;
KRUL, AM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV HOSP LEIDEN,DEPT INFECT DIS,POB 9600,2300 RC LEIDEN,NETHERLANDS
UNIV HOSP LEIDEN,DEPT INFECT DIS,POB 9600,2300 RC LEIDEN,NETHERLANDS
KRUL, AM
;
VANFURTH, R
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV HOSP LEIDEN,DEPT INFECT DIS,POB 9600,2300 RC LEIDEN,NETHERLANDS
UNIV HOSP LEIDEN,DEPT INFECT DIS,POB 9600,2300 RC LEIDEN,NETHERLANDS
VANFURTH, R
.
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES,
1988,
20
(06)
:649
-656
[8]
CEFAZOLIN AND CEPHRADINE - RELATIONSHIP BETWEEN ANTIBACTERIAL ACTIVITY INVITRO AND IN MICE EXPERIMENTALLY INFECTED WITH ESCHERICHIA-COLI
[J].
KUNST, MW
论文数:
0
引用数:
0
h-index:
0
机构:
STATE UNIV LEIDEN HOSP,DEPT CLIN PHARMACOL,LEIDEN,NETHERLANDS
STATE UNIV LEIDEN HOSP,DEPT CLIN PHARMACOL,LEIDEN,NETHERLANDS
KUNST, MW
;
MATTIE, H
论文数:
0
引用数:
0
h-index:
0
机构:
STATE UNIV LEIDEN HOSP,DEPT CLIN PHARMACOL,LEIDEN,NETHERLANDS
STATE UNIV LEIDEN HOSP,DEPT CLIN PHARMACOL,LEIDEN,NETHERLANDS
MATTIE, H
.
JOURNAL OF INFECTIOUS DISEASES,
1978,
137
(04)
:391
-402
[9]
PULSE DOSING VERSUS CONTINUOUS INFUSION OF ANTIBIOTICS - PHARMACOKINETIC-PHARMACODYNAMIC CONSIDERATIONS
[J].
LEBEL, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TORONTO,FAC PHARM,TORONTO M5S 1A1,ONTARIO,CANADA
LEBEL, M
;
SPINO, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TORONTO,FAC PHARM,TORONTO M5S 1A1,ONTARIO,CANADA
SPINO, M
.
CLINICAL PHARMACOKINETICS,
1988,
14
(02)
:71
-95
[10]
MATHEMATICAL-DESCRIPTION OF SHORT-TERM EFFECTS OF BETA-LACTAM ANTIBIOTICS ON BACTERIAL-GROWTH INVITRO
[J].
MATTIE, H
论文数:
0
引用数:
0
h-index:
0
MATTIE, H
.
CURRENT MICROBIOLOGY,
1978,
1
(02)
:105
-109
←
1
2
→
共 14 条
[1]
ROLE OF PHARMACOKINETICS IN THE OUTCOME OF INFECTIONS
[J].
DRUSANO, GL
论文数:
0
引用数:
0
h-index:
0
DRUSANO, GL
.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,
1988,
32
(03)
:289
-297
[2]
FLANDERS H, 1985, CALCULUS
[3]
CLINICAL PHARMACOLOGY OF CEFAMANDOLE AS COMPARED WITH CEPHALOTHIN
[J].
FONG, IW
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
FONG, IW
;
RALPH, ED
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
RALPH, ED
;
ENGELKING, ER
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
ENGELKING, ER
;
KIRBY, WMM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
KIRBY, WMM
.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,
1976,
9
(01)
:65
-69
[4]
EXPERIMENTAL-INFECTION WITH STREPTOCOCCUS-PNEUMONIAE IN MICE - CORRELATION OF INVITRO ACTIVITY AND PHARMACOKINETIC PARAMETERS WITH INVIVO EFFECT FOR 14 CEPHALOSPORINS
[J].
FRIMODTMOLLER, N
论文数:
0
引用数:
0
h-index:
0
机构:
STATENS SERUM INST,DEPT ANTHROPOL,DK-2300 COPENHAGEN S,DENMARK
FRIMODTMOLLER, N
;
BENTZON, MW
论文数:
0
引用数:
0
h-index:
0
机构:
STATENS SERUM INST,DEPT ANTHROPOL,DK-2300 COPENHAGEN S,DENMARK
BENTZON, MW
;
THOMSEN, VF
论文数:
0
引用数:
0
h-index:
0
机构:
STATENS SERUM INST,DEPT ANTHROPOL,DK-2300 COPENHAGEN S,DENMARK
THOMSEN, VF
.
JOURNAL OF INFECTIOUS DISEASES,
1986,
154
(03)
:511
-517
[5]
ANTIBIOTIC-THERAPY OF INFECTIONS DUE TO PSEUDOMONAS-AERUGINOSA IN NORMAL AND GRANULOCYTOPENIC MICE - COMPARISON OF MURINE AND HUMAN PHARMACOKINETICS
[J].
GERBER, AU
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BERN,INSELSPITAL,DEPT MED,CH-3010 BERN,SWITZERLAND
GERBER, AU
;
BRUGGER, HP
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BERN,INSELSPITAL,DEPT MED,CH-3010 BERN,SWITZERLAND
BRUGGER, HP
;
FELLER, C
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BERN,INSELSPITAL,DEPT MED,CH-3010 BERN,SWITZERLAND
FELLER, C
;
STRITZKO, T
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BERN,INSELSPITAL,DEPT MED,CH-3010 BERN,SWITZERLAND
STRITZKO, T
;
STALDER, B
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BERN,INSELSPITAL,DEPT MED,CH-3010 BERN,SWITZERLAND
STALDER, B
.
JOURNAL OF INFECTIOUS DISEASES,
1986,
153
(01)
:90
-97
[6]
UNDERSTANDING THE DOSE-EFFECT RELATIONSHIP - CLINICAL-APPLICATION OF PHARMACOKINETIC-PHARMACODYNAMIC MODELS
[J].
HOLFORD, NHG
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO, SCH MED, DEPT MED, DIV CLIN PHARMACOL, SAN FRANCISCO, CA 94143 USA
HOLFORD, NHG
;
SHEINER, LB
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO, SCH MED, DEPT MED, DIV CLIN PHARMACOL, SAN FRANCISCO, CA 94143 USA
SHEINER, LB
.
CLINICAL PHARMACOKINETICS,
1981,
6
(06)
:429
-453
[7]
THE EFFICACY OF RIFAMPICIN AGAINST STAPHYLOCOCCUS-AUREUS INVITRO AND IN AN EXPERIMENTAL-INFECTION IN NORMAL AND GRANULOCYTOPENIC MICE
[J].
HOOGETERP, JJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV HOSP LEIDEN,DEPT INFECT DIS,POB 9600,2300 RC LEIDEN,NETHERLANDS
UNIV HOSP LEIDEN,DEPT INFECT DIS,POB 9600,2300 RC LEIDEN,NETHERLANDS
HOOGETERP, JJ
;
MATTIE, H
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV HOSP LEIDEN,DEPT INFECT DIS,POB 9600,2300 RC LEIDEN,NETHERLANDS
UNIV HOSP LEIDEN,DEPT INFECT DIS,POB 9600,2300 RC LEIDEN,NETHERLANDS
MATTIE, H
;
KRUL, AM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV HOSP LEIDEN,DEPT INFECT DIS,POB 9600,2300 RC LEIDEN,NETHERLANDS
UNIV HOSP LEIDEN,DEPT INFECT DIS,POB 9600,2300 RC LEIDEN,NETHERLANDS
KRUL, AM
;
VANFURTH, R
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV HOSP LEIDEN,DEPT INFECT DIS,POB 9600,2300 RC LEIDEN,NETHERLANDS
UNIV HOSP LEIDEN,DEPT INFECT DIS,POB 9600,2300 RC LEIDEN,NETHERLANDS
VANFURTH, R
.
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES,
1988,
20
(06)
:649
-656
[8]
CEFAZOLIN AND CEPHRADINE - RELATIONSHIP BETWEEN ANTIBACTERIAL ACTIVITY INVITRO AND IN MICE EXPERIMENTALLY INFECTED WITH ESCHERICHIA-COLI
[J].
KUNST, MW
论文数:
0
引用数:
0
h-index:
0
机构:
STATE UNIV LEIDEN HOSP,DEPT CLIN PHARMACOL,LEIDEN,NETHERLANDS
STATE UNIV LEIDEN HOSP,DEPT CLIN PHARMACOL,LEIDEN,NETHERLANDS
KUNST, MW
;
MATTIE, H
论文数:
0
引用数:
0
h-index:
0
机构:
STATE UNIV LEIDEN HOSP,DEPT CLIN PHARMACOL,LEIDEN,NETHERLANDS
STATE UNIV LEIDEN HOSP,DEPT CLIN PHARMACOL,LEIDEN,NETHERLANDS
MATTIE, H
.
JOURNAL OF INFECTIOUS DISEASES,
1978,
137
(04)
:391
-402
[9]
PULSE DOSING VERSUS CONTINUOUS INFUSION OF ANTIBIOTICS - PHARMACOKINETIC-PHARMACODYNAMIC CONSIDERATIONS
[J].
LEBEL, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TORONTO,FAC PHARM,TORONTO M5S 1A1,ONTARIO,CANADA
LEBEL, M
;
SPINO, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TORONTO,FAC PHARM,TORONTO M5S 1A1,ONTARIO,CANADA
SPINO, M
.
CLINICAL PHARMACOKINETICS,
1988,
14
(02)
:71
-95
[10]
MATHEMATICAL-DESCRIPTION OF SHORT-TERM EFFECTS OF BETA-LACTAM ANTIBIOTICS ON BACTERIAL-GROWTH INVITRO
[J].
MATTIE, H
论文数:
0
引用数:
0
h-index:
0
MATTIE, H
.
CURRENT MICROBIOLOGY,
1978,
1
(02)
:105
-109
←
1
2
→