SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME 1-(2-PROPYNYL) AND 1-PROPADIENYL DERIVATIVES OF 1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDS AND SIMILAR HETEROCYCLES

被引：10

作者：

RADL, S

KOVAROVA, L

HOLUBEK, J

机构：

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1991年 / 56卷 / 02期

关键词：

D O I：

10.1135/cccc19910439

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N-Alkylation of IIIa, IIIb, IIId-IIIf, and 9-acridanone with 3-bromopropyne in dimethyl sulfoxide in the presence of potassium carbonate yielded N-(2-propynyl) derivatives IVa-IVe and VIa, respectively. Ethyl esters IVa, IVb, and IVe were hydrolyzed to IVf-IVh, respectively. Compounds IVf, IVg, IVc treated with bases yielded N-propadienyl derivatives Va-Vc. On the other hand 2-substituted compounds IVd and IVh did not change under the same conditions. Compound VIa treated with powdered potassium hydroxide in dimethyl sulfoxide at room temperature yielded N-(1-propynyl) derivative VII.

引用

页码：439 / 448

页数：10

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[2]

Aldridge G. R, 1967, U.S Patent, Patent No. [US3334102, 3334102]

[3]

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[4] SHORT SYNTHESES OF 1,2,3,5-TETRAHYDRO-5-OXOPYRROLO[1,2-A]QUINOLINE-4-CARBOXYLIC ACID AND 1,2,3,4-TETRAHYDRO-6H-6-OXOPYRIDO[1,2-A]QUINOLINE-5-CARBOXYLIC ACID-DERIVATIVES [J].