CALORIE RESTRICTION AND CELLULAR PROLIFERATION IN VARIOUS TISSUES OF THE FEMALE SWISS WEBSTER MOUSE

被引：112

作者：

LOK, E

SCOTT, FW

MONGEAU, R

NERA, EA

MALCOLM, S

CLAYSON, DB

机构：

[1] HLTH & WELF CANADA,HLTH PROTECT BRANCH,FOOD DIRECTORATE,BUR CHEM SAFETY,TOXICOL RES DIV,OTTAWA K1A 0L2,ONTARIO,CANADA

[2] BANTING RES CTR,OTTAWA K1A 0L2,ONTARIO,CANADA

[3] HLTH & WELF CANADA,HLTH PROTECT BRANCH,FOOD DIRECTORATE,BUR NUTR SCI,NUTR RES DIV,OTTAWA K1A 0L2,ONTARIO,CANADA

[4] HLTH & WELF CANADA,HLTH PROTECT BRANCH,FOOD DIRECTORATE,DIV FOOD STAT & OPERAT PLANNING,OTTAWA K1A 0L2,ONTARIO,CANADA

来源：

CANCER LETTERS | 1990年 / 51卷 / 01期

关键词：

calorie restriction; colo-rectum; female mouse; jejunum; mammary gland; [!sup]3[!/sup]H]thymidine labeling indices;

D O I：

10.1016/0304-3835(90)90232-M

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Two experiments have been conducted to determine the effects of calorie restriction on cellular proliferation in female mouse tissues. In the first experiment, 25% calorie restriction led to a decrease in cellular proliferation, measured by the [3H]thymidine labeling index, in each of the 7 tissues examined. The duct lining cells of the mammary gland were the most affected. This conclusion was confirmed in the second experiment in which levels of 0, 10, 20, 30 and 40% calorie restriction were employed. The difference in response of the duct cells of the mammary gland and the crypt cells of the colo-rectum is discussed in light of the opinion that the formation of cancer of these tissues in humans may be markedly affected by diet. © 1990.

引用

页码：67 / 73

页数：7

共 15 条

[1] EFFECT OF DIETARY RESTRICTION ON INDUCED HAMSTER-CHEEK POUCH CARCINOGENESIS [J].

ANDREOU, KK ;

MORGAN, PR .

ARCHIVES OF ORAL BIOLOGY, 1981, 26 (06) :525-531

[2]

BIERI JG, 1977, J NUTR, V107, P1340

[3] INTERNATIONAL-COMMISSION-FOR-PROTECTION-AGAINST-ENVIRONMENTAL-MUTAGENS-AND-CARCINOGENS - ICPEMC PUBLICATION NO-17 - CAN A MECHANISTIC RATIONALE BE PROVIDED FOR NON-GENOTOXIC CARCINOGENS IDENTIFIED IN RODENT BIOASSAYS [J].

CLAYSON, DB .

MUTATION RESEARCH, 1989, 221 (01) :53-67

[4] THE NEED FOR BIOLOGICAL RISK ASSESSMENT IN REACHING DECISIONS ABOUT CARCINOGENS [J].

CLAYSON, DB ;

JANSEN, JD .

MUTATION RESEARCH, 1987, 185 (03) :243-269

[5] PAIRWISE MULTIPLE COMPARISONS IN THE HOMOGENEOUS VARIANCE, UNEQUAL SAMPLE-SIZE CASE [J].

DUNNETT, CW .

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1980, 75 (372) :789-795

[6] STUDY OF POWERS OF SEVERAL METHODS OF MULTIPLE COMPARISONS [J].

EINOT, I ;

GABRIEL, KR .

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1975, 70 (351) :574-583

[7]

KOGA A, 1980, J NUTR SCI VITAMINOL, V26, P33, DOI 10.3177/jnsv.26.33

[8]

KOGA A, 1979, J NUTR SCI VITAMINOL, V25, P265, DOI 10.3177/jnsv.25.265

[9] DIETARY RESTRICTION, CELL-PROLIFERATION AND CARCINOGENESIS - A PRELIMINARY-STUDY [J].

LOK, E ;

NERA, EA ;

IVERSON, F ;

SCOTT, F ;

SO, Y ;

CLAYSON, DB .

CANCER LETTERS, 1988, 38 (03) :249-255

[10] SHORT-TERM PATHOLOGICAL AND PROLIFERATIVE EFFECTS OF BUTYLATED HYDROXYANISOLE AND OTHER PHENOLIC ANTIOXIDANTS IN THE FORESTOMACH OF FISCHER-344 RATS [J].

NERA, EA ;

LOK, E ;

IVERSON, F ;

ORMSBY, E ;

KARPINSKI, KF ;

CLAYSON, DB .

TOXICOLOGY, 1984, 32 (03) :197-213

← 1 2 →