A CONTROLLED-STUDY OF TC-99M-HMPAO SINGLE-PHOTON EMISSION IMAGING IN CHRONIC-SCHIZOPHRENIA

被引：113

作者：

LEWIS, SW

FORD, RA

SYED, GM

REVELEY, AM

TOONE, BK

机构：

[1] SPRINGFIELD HOSP, LONDON, ENGLAND

[2] UNIV LONDON KINGS COLL HOSP, DEPT NUCL MED, LONDON SE5 8RX, ENGLAND

[3] UNIV LONDON KINGS COLL HOSP, DEPT PSYCHIAT, LONDON SE5 8RX, ENGLAND

[4] MAUDSLEY HOSP & INST PSYCHIAT, DEPT PSYCHIAT, LONDON SE5 8AZ, ENGLAND

来源：

PSYCHOLOGICAL MEDICINE | 1992年 / 22卷 / 01期

关键词：

D O I：

10.1017/S0033291700032694

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Regional cerebral blood flow (rCBF) during a word fluency task was compared in twenty-five male, right-handed, medicated schizophrenic patients and twenty-five age-matched male, right-handed healthy volunteers, using technetium-99m-HMPAO multidetector single-photon emission tomography. Increased rCBF in caudate and thalamus was found in patients, probably secondary to neuroleptic medication. Patients showed decreased rCBF in left frontal cortical regions and increased rCBF in left posterior cortical regions, compared to controls. Patterns of left-sided frontal rCBF dominance in controls were reversed in patients, as were normal patterns of right-sided parietal rCBF dominance. Negative symptom score correlated inversely with mesial frontal rCBF, particularly on the left.

引用

页码：27 / 35

页数：9

共 40 条

[1]

ALLEN H, 1990, SCHIZOPHR RES, V3, P67

[2]

ANNETT M, 1970, BRIT J PSYCHOL, V6, P278

[3] CEREBRAL PERFUSION INHOMOGENEITIES IN SCHIZOPHRENIA DEMONSTRATED WITH SINGLE PHOTON-EMISSION COMPUTED-TOMOGRAPHY AND TC99M-HEXAMETHYLPROPYLENEAMINEOXIM [J].