PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE PROVOKES CULTURED RAT CHROMAFFIN CELLS TO SECRETE ADRENALINE

被引:176
作者
WATANABE, T
MASUO, Y
MATSUMOTO, H
SUZUKI, N
OHTAKI, T
MASUDA, Y
KITADA, C
TSUDA, M
FUJINO, M
机构
[1] Tsukuba Research Laboratories, Takeda Chemical Industries, Ltd., Tsukuba Ibaraki, 300-42
关键词
D O I
10.1016/S0006-291X(05)80159-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Pituitary adenylate cyclase activating polypeptide (PACAP) provoked the rat chromaffin cells to secrete adrenaline. Within 20 min, the amount of adrenaline secreted by PACAP (10-8M) was as much as that caused by acetylcholine (10-4M). PACAP, but not acetylcholine, induced a long-term (over 120 min) increase in secretion of adrenaline. PACAP also activated adenylate cyclase and elevated cytosolic Ca2+ concentration. Furthermore, we found immunoreactive PACAP and PACAP binding sites in the rat adrenal medulla. These results suggest that PACAP has an important role in stimulating secretion of adrenaline in the adrenal medulla. © 1992 Academic Press, Inc.
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收藏
页码:403 / 411
页数:9
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