AGING-RELATED CHANGES IN IGF-II AND C-FOS GENE-EXPRESSION IN THE RAT-BRAIN

被引：59

作者：

KITRAKI, E

BOZAS, E

PHILIPPIDIS, H

STYLIANOPOULOU, F

机构：

[1] UNIV ATHENS,BIOL & BIOCHEM LAB,POB 14224,GR-11510 ATHENS,GREECE

[2] UNIV ATHENS,HISTOL EMBRYOL LAB,GR-11510 ATHENS,GREECE

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 1993年 / 11卷 / 01期

关键词：

AGING; AGED BRAIN; IGF-II; C-FOS; MESSENGER RNA; DNA METHYLATION;

D O I：

10.1016/0736-5748(93)90029-D

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The protein products of growth factor genes such as IGF-II and cellular oncogenes such as c-fos are believed to be necessary for the support of normal neuronal function. Steady-state levels of c-fos and IGF-II mRNA were determined in the brain of young and old rats, using Northern analysis. Both RNAs were found to be decreased in the brain of aged rats. Age-related decrease was detected in the hippocampus, hypothalamus, striatum, cerebral cortex and cerebellum, for IGF-II mRNA. and in the cerebral cortex and cerebellum for c-fos mRNA. Furthermore, changes in the degree and pattern of DNA methylation were noted at both gene loci, in the aged rat brain. Our results could reflect changes at the genomic level possibly related to the process of aging and the accompanying decline in brain function.

引用

页码：1 / 9

页数：9

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