TOXICOLS AC AND TOXIUSOL - NEW BIOACTIVE HEXAPRENOID HYDROQUINONES FROM TOXICLONA-TOXIUS

被引：26

作者：

ISAACS, S

HIZI, A

KASHMAN, Y

机构：

[1] TEL AVIV UNIV,SCH CHEM,IL-69978 TEL AVIV,ISRAEL

[2] TEL AVIV UNIV,SCH MED,IL-69978 TEL AVIV,ISRAEL

来源：

TETRAHEDRON | 1993年 / 49卷 / 20期

关键词：

D O I：

10.1016/S0040-4020(01)85743-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new compounds of two unprecedented types, toxicols A-C (3-5) and toxiusol (8) have been isolated from the Red Sea sponge Toxiclona toxius. The four compounds are hexaprenoid hydroquinone sulfates consisting of two different polycyclic halves. The structure of all new compounds was determined mainly by 1D and 2D NMR measurements as well as some chemical transformations. Several of the new compounds were found in a preliminary study to inhibit the reverse transcriptase of human immuno deficiency virus (HIV) and to possess activity against Candida albicans.

引用

页码：4275 / 4282

页数：8

共 10 条

[1] DISIDEIN, A PENTACYCLIC SESTERTERPENE CONDENSED WITH AN HYDROXYHYDROQUINONE MOIETY, FROM SPONGE DISIDEA-PALLESCENS [J].