STRUCTURE AND ABSOLUTE-CONFIGURATION OF A HIGH-AFFINITY 5-HT3 RECEPTOR ANTAGONIST, (5AS,9AS)-N-[(3S)-1-AZABICYCLO[2.2.2]OCTAN-3-YL]-2-CHLORO-5A,6,7,8,9,9A-HEXAHYDRO-4-DIBENZOFURANCARBOXAMIDE HYDROCHLORIDE

被引：1

作者：

AMMON, HL ^{[1
]}

YOUSSEFYEH, RD ^{[1
]}

AIREY, JE ^{[1
]}

STUDT, WL ^{[1
]}

CAMPBELL, HF ^{[1
]}

POWERS, MR ^{[1
]}

GOLEC, FA ^{[1
]}

机构：

[1] RHONE POULENC RORER CENT RES,COLLEGEVILLE,PA

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1993年 / 49卷

关键词：

D O I：

10.1107/S0108270193000824

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The absolute configuration was established as (S,S,S) by the R-factor test and by careful measurement of 197 enantiomorph-sensitive Friedel pairs of reflections. The determination also confirms the absolute stereochemistry of (-)-3-aminoquinuclidine, a compound used in the preparation of the title material. The cyclohexane/tetrahydrofuran ring fusion is cis. The quinuclidine moiety has almost perfect threefold symmetry; the front and rear halves are twisted about this axis by 15-degrees. Quinuclidine-N-H...Cl- and amide-N-H...Cl hydrogen bonds link screw-dyad-related molecules along the b axis.

引用

页码：1551 / 1554

页数：4

共 14 条

[1] THE SEROTONIN TYPE-3 RECEPTOR ANTAGONIST BRL-43694 AND NAUSEA AND VOMITING INDUCED BY CISPLATIN [J].