METALATION OF DIAZINES .10. FIRST HALOGEN MIGRATION DURING METALATION OF PYRIMIDINES UNUSUAL HALOGEN-LITHIUM EXCHANGE WITH LTMP - NEW SYNTHESIS OF LESHMANIACIDES

被引：29

作者：

PLE, N ^{[1
]}

TURCK, A ^{[1
]}

COUTURE, K ^{[1
]}

QUEGUINER, G ^{[1
]}

机构：

[1] INSA,IRCOF,CHIM ORGAN FINE & HETEROCYCL LAB,CNRS,URA 1429,F-76131 MONT ST AIGNAN,FRANCE

来源：

TETRAHEDRON | 1994年 / 50卷 / 34期

关键词：

D O I：

10.1016/S0040-4020(01)81762-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An halogen migration of iodine during the metalation of pyrimidines has been highlighted and a mechanism is proposed. An unusual halogen-lithium exchange with LTMP has been observed. A new synthetic route to Leshmaniacides using metalation and cross coupling reactions is described.

引用

页码：10299 / 10308

页数：10

共 21 条

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