FACILITATORY EFFECT OF OLFACTORY BULBECTOMY ON 2-DEOXYGLUCOSE UPTAKE IN RAT AMYGDALA SLICES

被引：14

作者：

SHIBATA, S

WATANABE, S

机构：

[1] Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University 62, Fukuoka

来源：

BRAIN RESEARCH | 1994年 / 665卷 / 01期

关键词：

OLFACTORY BULBECTOMY; AMYGDALA; 2-DEOXYGLUCOSE; BRAIN SLICE; CEREBRAL CORTEX;

D O I：

10.1016/0006-8993(94)91165-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of the present study was to determine whether the 2-deoxyglucose uptake of amygdala slices was affected by olfactory bulbectomy. At 7, 14 and 21 days post-lesion, bilateral olfactory bulbectomized rats exhibited a significant increase of 2-deoxyglucose uptake in amygdala slices, but not in the cerebral cortex. In addition, unilateral olfactory bulbectomized rats showed a high uptake of 2-deoxyglucose uptake in the ipsilateral amygdala, but not in the contralateral amygdala. These results suggest that the enhancement of 2-deoxyglucose uptake is related to the hyperexcitability of amygdala neurons following bulbectomy, and that this enhancement may be responsible for the behavioral changes in olfactory bulbectomized rats.

引用

页码：147 / 150

页数：4

共 21 条

[1] POTENTIATION OF AMYGDALOID KINDLING AND METRAZOL-INDUCED SEIZURES BY 6-HYDROXYDOPAMINE IN RATS [J].