STRUCTURAL SIMILARITY BETWEEN THE PLECKSTRIN HOMOLOGY DOMAIN AND VEROTOXIN - THE PROBLEM OF MEASURING AND EVALUATING STRUCTURAL SIMILARITY

被引：18

作者：

ORENGO, CA

SWINDELLS, MB

MICHIE, AD

ZVELEBIL, MJ

DRISCOLL, PC

WATERFIELD, MD

THORNTON, JM

机构：

[1] YAMANOUCHI PHARMACEUT CO LTD,INST DRUG DISCOVERY RES,DEPT MOLEC DESIGN,TSUKUBA,IBARAKI 305,JAPAN

[2] UNIV LONDON UNIV COLL,DEPT BIOCHEM & MOLEC BIOL,LONDON WC1E 6BT,ENGLAND

[3] LUDWIG INST CANC RES,LONDON WC1E 8BP,ENGLAND

来源：

PROTEIN SCIENCE | 1995年 / 4卷 / 10期

关键词：

DATABASE; PH DOMAIN; STRUCTURE COMPARISON; STRUCTURAL SIMILARITY; VEROTOXIN;

D O I：

10.1002/pro.5560041003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An unexpected structural similarity is described between the pleckstrin homology (PH) domain and verotoxin. This similarity has escaped detection primarily due to the differences in topology that exist between the two proteins, By comparing this result with two previously reported similarities for the PH domain, one with the lipocalins and another with the FK506 binding protein, we discuss the problems of measuring and assessing structural similarities.

引用

页码：1977 / 1983

页数：7

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