SIGMA-ANTAGONISTS POTENTIATE OPIOID ANALGESIA IN RATS

被引：97

作者：

CHIEN, CC

PASTERNAK, GW

机构：

[1] MEM SLOAN KETTERING CANC CTR,COTZIAS LAB NEUROONCOL,NEW YORK,NY 10021

[2] CORNELL UNIV,COLL MED,DEPT NEUROL,ITHACA,NY

[3] CORNELL UNIV,COLL MED,DEPT NEUROSCI,ITHACA,NY

[4] CORNELL UNIV,COLL MED,DEPT PHARMACOL,ITHACA,NY

来源：

NEUROSCIENCE LETTERS | 1995年 / 190卷 / 02期

关键词：

OPIOID ANALGESIA; SIGMA(1) RECEPTORS;

D O I：

10.1016/0304-3940(95)11504-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In mice, activation of sigma(1) receptors antagonizes opioid analgesia. Sigma antagonists potentiate opioid analgesia, implying that the anti-opioid sigma system is tonically active. Go-administration of haloperidol with the mu opioid morphine, the kappa(1) analgesic U50,488H or the kappa(3) agonist naloxone benzoylhydrazone enhances the analgesic activity of all agents. The effect results from sigma receptor blockade since (-)sulpiride, a selective D-2 antagonist which does not block sigma receptors, is inactive.

引用

页码：137 / 139

页数：3

共 21 条

[1] SIGMA-RECEPTORS NEGATIVELY MODULATE AGONIST-STIMULATED PHOSPHOINOSITIDE METABOLISM IN RAT-BRAIN [J].