COLOCALIZATION OF THE RAT HOMOLOG OF THE VONHIPPEL-LINDAU (VHL) GENE AND THE PLASMA-MEMBRANE CA++ TRANSPORTING ATPASE-ISOFORM-2 (ATP2B2) GENE TO RAT CHROMOSOME BANDS 4Q41.3-]42.1

Using fluorescence in situ hybridization, we localized the rat homolog of the von Hippel-Lindau gene (Vhl) to rat chromosome band 4q41.3-->q42.1. We also mapped the gene encoding the plasma membrane Ca++-transporting ATPase isoform 2 (Atp2b2) to the same chromosome subregion. These two genes together with Raf1 appear to be members of a large syntenic gene cluster that maps to human chromosome bands 3p25 --> p26, mouse chromosome bands 6 C3 --> E, and rat chromosome bands 4q41 --> q42. Cytogenetic analysis of NRK 52E cells derived from immortalized normal rat kidney epithelial cells revealed an inverted duplication of the region containing this gene cluster.