A NEW ACHIRAL REAGENT FOR THE INCORPORATION OF MULTIPLE AMINO-GROUPS INTO OLIGONUCLEOTIDES

被引：6

作者：

BEHRENS, C

PETERSEN, KH

EGHOLM, M

NIELSEN, J

BUCHARDT, O

DAHL, O

机构：

[1] Research Center for Medical Biotechnology, Department of Chemistry, University of Copenhagen, DK-2100 Copenhagen

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 16期

关键词：

D O I：

10.1016/0960-894X(95)00315-K

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a new functionalized achiral linker reagent (10) for the incorporation of multiple primary amino groups into oligonucleotides is described. The linker reagent is compatible with conventional DNA-synthesis following the phosphoramidite methodology, and the linker can be incorporated in good yield.

引用

页码：1785 / 1790

页数：6

共 19 条

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