RADIOULNAR SYNOSTOSIS BEHAVIORAL DISTURBANCE AND XYY CHROMOSOMES

Two prepubertal boys with radioulnar synostosis, aggressive behavior, mild retardation, and tall stature were found to have an XYY chromosomal constitution. The chromosomal abnormality in one of them was found by testing 6 patients, 4 of whom were boys with radioulnar synostosis. This suggested a close relationship between the extra Y chromosome and this skeletal abnormality. Violent, criminal tendencies have been reported in male adults with extra Y chromosomes. Disturbance in childhood may be an expression of this pattern or an indication of a much broader relationship between chromosomal composition and behavior. © 1969 The C. V. Mosby Company.