PHOTO-TOXICITY OF CHLORPROMAZINE

被引：16

作者：

BUNCE, NJ

KUMAR, Y

RAVANAL, L

机构：

[1] Chemistry Department, University of Guelph, Guelph, Ontario

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 02期

关键词：

D O I：

10.1021/jm00188a016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The constitution of chlorpromazine has been studied in the context of its phototoxicity. Electron transfer from the side chain to the aromatic nucleus of the drug contributes to its instability to light. Even without the side chain, however, chlorophenothiazines appear to be very photolabile, so that it is unlikely that nonphototoxic analogues of chlorpromazine can be prepared merely by altering the constitution of the side chain. © 1979, American Chemical Society. All rights reserved.

引用

页码：202 / 204

页数：3

共 14 条

[1] MODIFICATION OF CHLOROBENZENE PHOTOREACTIVITY THROUGH EXCIPLEX FORMATION
BUNCE, NJ
RAVANAL, L
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (12) : 4150 - 4152
[2] ELECTRON-TRANSFER ON PHOTOLYSIS OF 1-CHLORONAPHTHALENE IN ALKANE SOLVENTS
BUNCE, NJ
PILON, P
RUZO, LO
STURCH, DJ
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (18) : 3023 - 3025
[3] CALVERT JG, 1966, PHOTOCHEMISTRY, P783
[4] PHOTOCHEMISTRY OF CHLORPROMAZINE [2-CHLORO-N-(3-DIMETHYLAMINOPROPYL)PHENOTHIAZINE] IN PROPAN-2-OL SOLUTION
DAVIES, AK
NAVARATNAM, S
PHILLIPS, GO
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1976, (01): : 25 - 29
[5] GRANT FW, 1974, PHENOTHIAZINES STRUC, P539
[6] CONTACT PHOTOSENSITIVITY PATTERNS TO HALOGENATED SALICYLANILIDES - IN MAN AND GUINEA PIGS
HARBER, LC
TARGOVNIK, SE
BAER, RL
[J]. ARCHIVES OF DERMATOLOGY, 1967, 96 (06) : 646 - +
[7] INTERMEDIATE STATE IN PHOTOIONIZATION OF CHLORPROMAZINE IN ETHANOL
IWAOKA, T
KONDO, M
[J]. CHEMISTRY LETTERS, 1976, (10) : 1105 - 1108
[8] PHOTOIONIZATION OF CHLORPROMAZINE HYDROCHLORIDE IN BINARY MIXED-SOLVENT SYSTEMS
IWAOKA, T
KONDO, M
[J]. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1977, 50 (01) : 1 - 5
[9] KAN RO, 1966, ORGANIC PHOTOCHEMIST, P10
[10] OHASHI M, 1973, J CHEM SOC CHEM COMM, P384

← 1 2 →