ESTIMATION OF PHARMACOKINETIC PARAMETERS OF 2-COMPARTMENT OPEN MODEL FROM POST-INFUSION PLASMA CONCENTRATION DATA

A model is presented which can serve as a means for obtaining the pharmacokinetic parameters of the two‐compartment open system for drugs which are too poorly soluble or too irritating to be administered by rapid intravenous injection. Experimentally, this method involves administering the drug by constant rate intravenous infusion, until the attainment of infusion equilibrium, and determining the plasma concentrations of drug in the postinfusion period. This approach has been applied to literature data and has resulted in the evaluation of the two‐compartment pharmacokinetics of oxacillin. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company