MEVINOLIN (LOVASTATIN) INHIBITS ANDROSTENEDIONE PRODUCTION BY PORCINE OVARIAN THECA CELLS AT THE LEVEL OF THE 17-ALPHA-HYDROXYLASE-C-17,20-LYASE COMPLEX

被引:22
作者
ENGELHARDT, H
GORELANGTON, RE
ARMSTRONG, DT
机构
[1] JOHN P ROBARTS RES INST,LONDON N6A 5A5,ONTARIO,CANADA
[2] UNIV WESTERN ONTARIO,DEPT PHYSIOL,LONDON N6A 3K7,ONTARIO,CANADA
[3] UNIV WESTERN ONTARIO,DEPT OBSTET & GYNECOL,LONDON N6A 3K7,ONTARIO,CANADA
关键词
D O I
10.1210/endo-124-5-2297
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:2297 / 2304
页数:8
相关论文
共 43 条
  • [1] MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT
    ALBERTS, AW
    CHEN, J
    KURON, G
    HUNT, V
    HUFF, J
    HOFFMAN, C
    ROTHROCK, J
    LOPEZ, M
    JOSHUA, H
    HARRIS, E
    PATCHETT, A
    MONAGHAN, R
    CURRIE, S
    STAPLEY, E
    ALBERSSCHONBERG, G
    HENSENS, O
    HIRSHFIELD, J
    HOOGSTEEN, K
    LIESCH, J
    SPRINGER, J
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07): : 3957 - 3961
  • [2] RECEPTOR-MEDIATED GONADOTROPIN ACTION IN THE OVARY - DEMONSTRATION OF ACUTE DEPENDENCE OF RAT LUTEAL CELLS ON EXOGENOUSLY SUPPLIED STEROID PRECURSOR (STEROLS) FOR GONADOTROPIN-INDUCED STEROIDOGENESIS
    AZHAR, S
    MENON, M
    MENON, KMJ
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1981, 665 (03) : 362 - 375
  • [3] CRYSTAL AND MOLECULAR-STRUCTURE OF COMPACTIN, A NEW ANTIFUNGAL METABOLITE FROM PENICILLIUM-BREVICOMPACTUM
    BROWN, AG
    SMALE, TC
    KING, TJ
    HASENKAMP, R
    THOMPSON, RH
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (11): : 1165 - 1173
  • [4] BROWN MS, 1978, J BIOL CHEM, V253, P1121
  • [5] ACTIVITY OF 3-BETA-HYDROXY-DELTA-5-STEROID DEHYDROGENASE-DELTA-5-DELTA-4-ISOMERASE IN THE OVINE CORPUS-LUTEUM
    CAFFREY, JL
    NETT, TM
    ABEL, JH
    NISWENDER, GD
    [J]. BIOLOGY OF REPRODUCTION, 1979, 20 (02) : 279 - 287
  • [6] PORCINE OVARIAN FOLLICLE .1. SELECTED CHEMICAL-ANALYSIS OF FOLLICULAR-FLUID AT DIFFERENT DEVELOPMENTAL STAGES
    CHANG, SCS
    JONES, JD
    ELLEFSON, RD
    RYAN, RJ
    [J]. BIOLOGY OF REPRODUCTION, 1976, 15 (03) : 321 - 328
  • [7] INHIBITORS OF ADRENAL CORTICOSTEROID 17ALPHA-HYDROXYLATION
    CHART, JJ
    HOWIE, N
    SHEPPARD, H
    MOWLES, T
    [J]. ENDOCRINOLOGY, 1962, 71 (03) : 479 - &
  • [8] EFFECT OF REDUCED BLOOD CHOLESTEROL ON STEROL AND STEROID-METABOLISM BY RAT LUTEAL TISSUE
    CHRISTIE, MH
    STRAUSS, JF
    FLICKINGER, GL
    [J]. ENDOCRINOLOGY, 1979, 105 (01) : 92 - 98
  • [9] COMPETITIVE INHIBITION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE BY ML-236A AND ML-236B FUNGAL METABOLITES, HAVING HYPOCHOLESTEROLEMIC ACTIVITY
    ENDO, A
    KURODA, M
    TANZAWA, K
    [J]. FEBS LETTERS, 1976, 72 (02) : 323 - 326
  • [10] TESTICULAR FUNCTION IN TYPE-II HYPERLIPOPROTEINEMIC PATIENTS TREATED WITH LOVASTATIN (MEVINOLIN) OR NEOMYCIN
    FARNSWORTH, WH
    HOEG, JM
    MAHER, M
    BRITTAIN, EH
    SHERINS, RJ
    BREWER, HB
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 65 (03) : 546 - 550