THE GENE ENCODING L1, A NEURAL ADHESION MOLECULE OF THE IMMUNOGLOBULIN FAMILY, IS LOCATED ON THE X-CHROMOSOME IN MOUSE AND MAN

被引：61

作者：

DJABALI, M

MATTEI, MG

NGUYEN, C

ROUX, D

DEMENGEOT, J

DENIZOT, F

MOOS, M

SCHACHNER, M

GORIDIS, C

JORDAN, BR

机构：

[1] HOP ENFANTS LA TIMONE,INSERM,U242,F-13385 MARSEILLE,FRANCE

[2] INST NEUROBIOL,W-6900 HEIDELBERG,GERMANY

来源：

GENOMICS | 1990年 / 7卷 / 04期

关键词：

D O I：

10.1016/0888-7543(90)90203-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The murine and human genes for the L1 neural adhesion molecule were shown to lie on conserved regions of the X chromosome to which genes responsible for several neuromuscular diseases have been mapped and which are adjacent to the fragile site (FRAXA) associated with mental retardation. By pulsed-field gel mapping we have demonstrated physical linkage between the L1 gene and other genes located in Xq28: L1 lies between the eye pigment RCP,GCP locus and the glucose-6-phosphate dehydrogenase (G6PD) gene. This location is compatible with the implication of the L1 molecule in one of the X-linked neuromuscular diseases mapped to this region. © 1990.

引用

页码：587 / 593

页数：7

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