REGIONAL CEREBRAL BLOOD-FLOW IN PATIENTS WITH SCHIZOPHRENIA - A PRELIMINARY-REPORT

被引:61
作者
KAWASAKI, Y
SUZUKI, M
MAEDA, Y
URATA, K
YAMAGUCHI, N
MATSUDA, H
HISADA, K
SUZUKI, M
TAKASHIMA, T
机构
[1] KANAZAWA UNIV,SCH MED,DEPT NUCL MED,KANAZAWA,ISHIKAWA 920,JAPAN
[2] KANAZAWA UNIV,SCH MED,DEPT RADIOL,KANAZAWA,ISHIKAWA 920,JAPAN
关键词
REGIONAL CEREBRAL BLOOD FLOW; TC99M-HMPAO SPECT; SCHIZOPHRENIA;
D O I
10.1007/BF02190252
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Regional cerebral blood flow was evaluated using Tc99m-HMPAO SPECT in 10 medicated patients with schizophrenia and 9 healthy volunteers. There were no prefrontal regions in the patient group with lower regional indices than in the control group. However, in the left hippocampal region, relative blood flow was significantly increased in the patient group compared with the control group. Furthermore, there was a relative increase in blood flow in the left basal ganglia of the patient group. A negative correlation coefficient was calculated between the relative blood flow in the left middle prefrontal cortex and the severity of the blunted affect, as well as between the relative blood flow in the left basal ganglia and the severity of the anhedonia-asociality. These findings indicate that prefrontal hypoactivity is not invariably present in all schizophrenics and that left basal ganglial hyperactivity may be associated with the effects of anti-psychotic treatment and clinical improvement. Moreover, the left hippocampal hyperactivity may correspond to left limbic dysfunction in schizophrenia.
引用
收藏
页码:195 / 200
页数:6
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