SEPARATION OF THEOPHYLLINE AND ITS ANALOGS BY MICELLAR ELECTROKINETIC CHROMATOGRAPHY - APPLICATION TO THE DETERMINATION OF THEOPHYLLINE IN HUMAN PLASMA

被引：29

作者：

LEE, KJ ^{[1
]}

HEO, GS ^{[1
]}

KIM, NJ ^{[1
]}

MOON, DC ^{[1
]}

机构：

[1] CHUNGBUK NATL UNIV,COLL PHARM,CHONGJU 303763,SOUTH KOREA

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 577卷 / 01期

关键词：

D O I：

10.1016/0378-4347(92)80608-S

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Micellar electrokinetic chromatographic separation of theophylline and its analogues was investigated using sodium dodecyl sulphate (SDS) as a micellar phase. The effects of pH, micelle concentration, applied voltage and temperature on the separation and preliminary quantitative analysis were studied for the determination of theophylline in human plasma. The data indicate that this technique could be used as the reference or routine method of theophylline measurement in therapeutic drug monitoring.

引用

页码：135 / 141

页数：7

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