ISOLATION AND SEQUENCE OF A MOUSE-BRAIN CDNA CODING FOR PROTEIN KINASE-C-GAMMA ISOZYME

被引：7

作者：

BOWERS, BJ

PARHAM, CL

SIKELA, JM

WEHNER, JM

机构：

[1] UNIV COLORADO,HLTH SCI CTR,DEPT PHARMACOL,DENVER,CO 80262

[2] UNIV COLORADO,SCH PHARM,BOULDER,CO 80309

来源：

GENE | 1993年 / 123卷 / 02期

关键词：

PK-C-GAMMA; RAT; HOMOLOGIES; GENE FAMILY; RECOMBINANT DNA;

D O I：

10.1016/0378-1119(93)90135-P

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The regulatory enzyme, protein kinase C (PKC), is characterized by a family of related isozymes. Currently, nucleotide (nt) sequences for seven members of this family have been reported from the bovine, human and rat genomes. Only four of these seven PKC isoforms have been isolated in mouse: alpha, beta(II), delta and epsilon. Here, we report the cDNA sequence encoding mouse PKC-gamma isolated from a C57BL/6 brain cDNA library. The mouse and rat PKC-gamma nt and deduced amino acid sequences share 97 and 100% identity, respectively.

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页码：263 / 265

页数：3

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