MOLECULAR MECHANICS OF NUCLEIC-ACID SEQUENCE AMPLIFICATION

被引：17

作者：

LANDEGREN, U

机构：

[1] Department of Medical Genetics, Uppsala Biomedical Center

来源：

TRENDS IN GENETICS | 1993年 / 9卷 / 06期

关键词：

D O I：

10.1016/0168-9525(93)90119-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Protocols for in vitro amplification of nucleic acids are proliferating and there are now several methods that will contribute both to genetic research and to the diagnosis of a wide range of diseases. Here, I present the working principles of some of these molecular machines for amplifying DNA or RNA and discuss the lines along which new methods of amplifying nucleic acids may be developed.

引用

收藏

页码：199 / 204

页数：6

相关论文

共 49 条

[41]

SEGEV D, 1990, Patent No. 9001069

[42]

STANLEY CJ, 1992, Patent No. 9204470

[43] INVITRO GENETICS [J].

SZOSTAK, JW .

TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (03) :89-93

[44] A NOISE-FREE MOLECULAR HYBRIDIZATION PROCEDURE FOR MEASURING RNA IN CELL LYSATES [J].

THOMPSON, J ;

SOLOMON, R ;

PELLEGRINO, M ;

SAKAI, K ;

LEWIN, M ;

FEILD, M ;

CASTROVINCI, M ;

SACRAMONE, L ;

GILLESPIE, D .

ANALYTICAL BIOCHEMISTRY, 1989, 181 (02) :371-378

[45] FLUORESCENCE INSITU HYBRIDIZATION - APPLICATIONS IN CYTOGENETICS AND GENE-MAPPING [J].

TRASK, BJ .

TRENDS IN GENETICS, 1991, 7 (05) :149-154

[46] STRAND DISPLACEMENT AMPLIFICATION - AN ISOTHERMAL, INVITRO DNA AMPLIFICATION TECHNIQUE [J].

WALKER, GT ;

FRAISER, MS ;

SCHRAM, JL ;

LITTLE, MC ;

NADEAU, JG ;

MALINOWSKI, DP .

NUCLEIC ACIDS RESEARCH, 1992, 20 (07) :1691-1696

[47] ISOTHERMAL INVITRO AMPLIFICATION OF DNA BY A RESTRICTION ENZYME DNA-POLYMERASE SYSTEM [J].

WALKER, GT ;

LITTLE, MC ;

NADEAU, JG ;

SHANK, DD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (01) :392-396

[48] SPECIFICITY OF THE NICK-CLOSING ACTIVITY OF BACTERIOPHAGE-T4 DNA-LIGASE [J].

WU, DY ;

WALLACE, RB .

GENE, 1989, 76 (02) :245-254

[49] THE LIGATION AMPLIFICATION REACTION (LAR) - AMPLIFICATION OF SPECIFIC DNA-SEQUENCES USING SEQUENTIAL ROUNDS OF TEMPLATE-DEPENDENT LIGATION [J].

WU, DY ;

WALLACE, RB .

GENOMICS, 1989, 4 (04) :560-569

← 1 2 3 4 5 →