MECHANISMS OF HORMONE RESISTANCE IN BREAST-CANCER

被引：71

作者：

HORWITZ, KB

机构：

[1] Department of Medicine, University of Colorado Health Sciences Center, Denver, 80262, Colorado

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1993年 / 26卷 / 02期

关键词：

ANTIESTROGENS; ENDOCRINE THERAPY; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; RESISTANCE; SPLICING; TAMOXIFEN; VARIANT RECEPTORS;

D O I：

10.1007/BF00689685

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

At least half of all advanced breast cancers are positive for estrogen receptor (ER) and progesterone receptor (PR), but many nevertheless fail to respond to endocrine therapy. Studies of breast cancer cell lines and breast tumor specimens are beginning to reveal molecular heterogeneity of the receptors in subpopulations of these cells, leading to altered receptor function and sometimes to hormone resistance. Here we will review the data on molecular and cellular heterogeneity involving ER and PR, and possible underlying mechanisms of resistance to tamoxifen and progestins.

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页码：119 / 130

页数：12

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