INVITRO SKIN PENETRATION OF PROPRANOLOL ENANTIOMERS

被引：23

作者：

HEARD, CM ^{[1
]}

WATKINSON, AC ^{[1
]}

BRAIN, KR ^{[1
]}

HADGRAFT, J ^{[1
]}

机构：

[1] ANEX,CARDIFF CF1 3XF,WALES

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 90卷 / 03期

关键词：

PERCUTANEOUS PENETRATION; ENANTIOSELECTIVE TRANSFER; PROPRANOLOL; ENANTIOMER; INVITRO PENETRATION;

D O I：

10.1016/0378-5173(93)90202-Q

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Transfer rates of individual enantiomers of propranolol across human skin were determined in Vitro. Percutaneous penetration of propranolol from propylene glycol was negligible at the concentration previously reported to show enantioselective transfer in rat skin. Transfer of (R)- and (S)-propranolol from aqueous solutions of both the racemate and the pure enantiomers showed no differences in the rates of penetration demonstrating that the rate of transfer of propranolol across human skin from these solutions was independent of the stereochemistry of the drug. In addition there was no evidence for racemisation during the transfer process.

引用

页码：R5 / R8

页数：4

共 7 条

[1]

BRIDGES J W, 1991, P1

[2]

GREEN PG, 1988, THESIS U WALES

[3]

HEARD CM, 1992, 1ST P ANN UK C, P28

[4] SKIN PENETRATION AND METABOLISM OF TOPICALLY APPLIED CHEMICALS IN 6 MAMMALIAN-SPECIES, INCLUDING MAN - AN INVITRO STUDY WITH BENZO[A]PYRENE AND TESTOSTERONE [J].