THE APPLICATION OF ELECTROSPRAY AND NEUTRAL-LOSS MASS-SPECTROMETRY TO THE IDENTIFICATION OF THE METABOLITES OF S12813 IN RAT-LIVER SLICES

被引：13

作者：

BROWNSILL, R ^{[1
]}

COMBAL, JP ^{[1
]}

TAYLOR, A ^{[1
]}

BERTRAND, M ^{[1
]}

LUIJTEN, W ^{[1
]}

WALTHER, B ^{[1
]}

机构：

[1] TECHNOL SERVIER,F-45007 ORLEANS,FRANCE

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1994年 / 8卷 / 05期

关键词：

D O I：

10.1002/rcm.1290080504

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The metabolism of S12813, (3-{2-[4-phenyl piperazin-1-yl] ethyl}-2-oxo-2,3-dihydro oxazolo [4, 5-b] pyridine chlorohydrate), in rat liver slice incubates was examined by high performance liquid chromatography combined with mass spectrometry. Electrospray ionization was used together with tandem mass spectrometric techniques of analysis (MS/MS). Polar phase I and phase II metabolites were identified as C-oxidation products, which were then conjugated to form either sulphate or glucuronide metabolites. On the basis of the identifications made, a metabolic pathway of S12813 in rat liver slices has been proposed.

引用

页码：361 / 365

页数：5