EFFECTS OF SINGLE AND COMBINED APPLICATION OF ANTICANCER DRUGS ON CERVICAL ADENOCARCINOMA .1. ANTITUMOR-ACTIVITY IN-VITRO

被引：7

作者：

HARA, K ^{[1
]}

IWASAKA, T ^{[1
]}

MATSUO, N ^{[1
]}

NAKAO, Y ^{[1
]}

YOKOYAMA, M ^{[1
]}

YAMASAKI, F ^{[1
]}

MVULA, M ^{[1
]}

SUGIMORI, H ^{[1
]}

机构：

[1] SAGA MED SCH,DEPT OBSTET & GYNECOL,NABESHIMA,SAGA 849,JAPAN

来源：

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA | 1995年 / 74卷 / 05期

关键词：

ADENOCARCINOMA; CERVICAL CARCINOMA; COMBINATION CHEMOTHERAPY; INTERFERON-GAMMA; IN VITRO;

D O I：

10.3109/00016349509024423

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Background. Establishment of effective combination chemotherapy regimen for patients with an adenocarcinoma of the uterine cervix has been long-awaited because there has been no documentation concerning chemosensitivity of this tumor against conventional antitumor agents. Methods. To search for an effective combination regimen, 15 conventional antitumor drugs were tested for growth inhibitory effects on five different cervical adenocarcinoma cell lines. Results. Etoposide, mitomycin C, adriamycin, epirubicin, and vinblastine, were singularly effective. Effects of combination chemotherapy were also tested using the above five antitumor agents plus interferon-gamma. Etoposide, mitomycin C, and interferon-gamma were the most effective when given in combination. Conclusions. Combined treatment with the above three drugs seems worthy of consideration for clinical application.

引用

页码：330 / 335

页数：6

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